Tardugno Roberta, Pellati Federica, Iseppi Ramona, Bondi Moreno, Bruzzesi Giacomo, Benvenuti Stefania
a Department of Life Sciences , University of Modena and Reggio Emilia , Modena , Italy.
b Department of Surgical, Medical, Dental and Morphological Sciences with Interest Transplant, Oncological and Regenerative Medicine , University of Modena and Reggio Emilia , Modena , Italy.
Nat Prod Res. 2018 Mar;32(5):544-551. doi: 10.1080/14786419.2017.1329730. Epub 2017 May 17.
In this study, the activity of essential oils (EOs) against microorganisms involved in oral diseases was evaluated. Fourteen EOs were selected and subjected to gas chromatographic analysis, including Illicium verum, Eucaliptus globulus, Eugenia caryophyllata, Leptospermum scoparium, Mentha arvensis, Mentha piperita, Myrtus communis, Salvia officinalis, Melaleuca alternifolia, Rosmarinus officinalis, Lavandula x intermedia, Thymus capitatus and Thymus vulgaris. These EOs were tested for their antimicrobial activity on Streptococcus mutans and Lactobacillus species clinically isolated from dental surgery patients. The antibacterial activity was evaluated by means of the disc diffusion and the minimum inhibitory concentration (MIC). Five EOs, having shown an interesting antimicrobial activity, were selected for a second screening in combination between them and with chlorhexidine. From the second assays, two EO-EO and three EO-chlorhexidine associations gave interesting results as potential constituents of mouthwashes, especially for the contribution of oxygenated monoterpenes, including menthol, thymol and carvacrol.
在本研究中，评估了香精油（EOs）对口腔疾病相关微生物的活性。选择了14种香精油并进行气相色谱分析，包括八角茴香、蓝桉、丁香、细叶桉、薄荷、胡椒薄荷、香桃木、鼠尾草、互叶白千层、迷迭香、杂薰衣草、头状百里香和百里香。对这些香精油针对从牙科手术患者临床分离出的变形链球菌和乳杆菌属的抗菌活性进行了测试。通过纸片扩散法和最低抑菌浓度（MIC）评估抗菌活性。选择了5种显示出有趣抗菌活性的香精油进行它们之间以及与氯己定联合的二次筛选。从第二次试验中，两种香精油-香精油组合和三种香精油-氯己定组合作为漱口水的潜在成分给出了有趣的结果，特别是对于含氧化单萜类化合物（包括薄荷醇、百里香酚和香芹酚）的贡献。
