局部用霉酚酸酯治疗白癜风：一项初步研究。
Topical mycophenolate mofetil in the treatment of vitiligo: a pilot study.
作者信息
Handjani Farhad, Aghaei Shahin, Moezzi Iman, Saki Nasrin
机构信息
Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Dermatology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Dermatol Pract Concept. 2017 Apr 30;7(2):31-33. doi: 10.5826/dpc.0702a06. eCollection 2017 Apr.
BACKGROUND
Vitiligo is a multifactorial disease that is characterized by circumscribed depigmented macules and patches. Autoimmune reactions may play an important role in the pathogenesis of the disease. Mycophenolate mofetil is a drug that inhibits DNA synthesis in lymphocytes and has been used in autoimmune diseases such as immunobullous skin diseases, lupus erythematosus, and autoimmune hepatitis.
OBJECTIVES
The objective of this study was to show the efficacy of topical mycophenolate mofetil in the treatment of vitiligo.
METHODS
Thirty patients with limited vitiligo were enrolled in this study. The patients applied a topical preparation of mycophenolate mofetil 15% twice daily for three months and at the end of every month, repigmentation was assessed using the Vitiligo Area Scoring Index (VASI).
RESULTS
At the end of the third month, 36.6 % (n=11) of the patients showed about 25% repigmentation of the lesions. No side effects were observed throughout the study.
CONCLUSION
This study showed that topical mycophenolate mofetil can be somewhat effective in the treatment of vitiligo; however, it seems to be inferior to potent topical steroids in inducing repigmentation.
背景
白癜风是一种多因素疾病，其特征为局限性色素脱失斑和斑块。自身免疫反应可能在该疾病的发病机制中起重要作用。霉酚酸酯是一种抑制淋巴细胞中DNA合成的药物，已用于免疫性大疱性皮肤病、红斑狼疮和自身免疫性肝炎等自身免疫性疾病。
目的
本研究的目的是显示外用霉酚酸酯治疗白癜风的疗效。
方法
30例局限性白癜风患者纳入本研究。患者每天两次外用15%霉酚酸酯制剂，持续三个月，每月末使用白癜风面积评分指数（VASI）评估色素恢复情况。
结果
第三个月末，36.6%（n=11）的患者皮损色素恢复约25%。整个研究过程中未观察到副作用。
结论
本研究表明，外用霉酚酸酯在治疗白癜风方面可能有一定疗效；然而，在诱导色素恢复方面似乎不如强效外用类固醇。
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