通过补充维生素、矿物质和多酚治疗白癜风。
Vitiligo treatment with vitamins, minerals and polyphenol supplementation.
作者信息
Jalel Akrem, Soumaya Gaigi Siala, Hamdaoui Mohamed Hédi
机构信息
Unité de Recherche sur les Composés Antioxydants, Stress Oxydant, Eléments Traces et Maladies Métaboliques, Ecole Supérieure des Sciences et Techniques de la Santé de Tunis, Tunisia.
出版信息
Indian J Dermatol. 2009;54(4):357-60. doi: 10.4103/0019-5154.57613.
BACKGROUND
Mammalian pigmentation results from the synthesis and accumulation of photo protective epidermal melanin. Melanin was formed from the amino acid precursor L-tyrosine within specialized cells, the melanocytes. Oxidative stress has been suggested to be the initial pathogenetic event in melanocyte degeneration with H(2)O(2) accumulation in the epidermis of patients with active disease. Auto immunity has been also suggested as another hypothesis in the pathogenesis of depigmentation disorders. Topical corticosteroids and phototherapy as common treatment modalities have been prescribed in patients with vitiligo. However, they are often not effective and safe (epidermal atrophy). Therefore, research for alternative therapies continues.
AIMS
To evaluate the beneficial effects of a supplementation with antioxidant vitamins (A, C, E) and minerals (zinc, selenium) for vitiligo treatment.
METHODS
Forty experimental autoimmune vitiligo mice C57BL6, aged from 5 to 12 months showing visible signs of induced vitiligo, were sequentially randomized into five parallel groups (8 mice per group). Each group mice was allocated an identical pre coded cage. the first group (SZV) received the ED + 1,4 g zinc (Zn) + 0.04 g selenium (Se) + vitamins (A 118 UI, C 8,5 mg, E 5,4 UI) /kg diet, the second group (PSZV) received the ED + 1,4 g zinc (Zn) + 0.04 g selenium (Se) + vitamins (A 118 UI, C 8.5 mg, E 5,4 UI)/kg diet + Polyphenol orally, the group 3 (PSZ) received the ED + green tea decoction prepared from 100 g/l (polyphenol orally) + 1,4 g Zn + 0.04 g Se, the 4 (P) received the ED + green tea decoction prepared green tea decoction prepared from 100 g/l, the control group 5(C) received the ED + distilled water. Cure was defined as repigmentation of treated sites. Photographic and optical techniques were used both at the baseline and on weekly basis.
RESULTS
By the end of the study, mice showed visible repigmentation. Using the investigator's global assessment, therapeutic success in terms of a clear repigmentation documented in 70% of treated mice.
CONCLUSION
Our findings suggest that an antioxidant supplementation is significantly beneficial in contributing superior clinical efficacy to cure vitiligo.
背景
哺乳动物的色素沉着源于具有光保护作用的表皮黑色素的合成与积累。黑色素由氨基酸前体L-酪氨酸在特殊细胞即黑素细胞内形成。氧化应激被认为是黑素细胞变性的初始致病事件，在活动性疾病患者的表皮中会积累过氧化氢。自身免疫也被认为是色素脱失性疾病发病机制中的另一种假说。外用糖皮质激素和光疗是白癜风患者常用的治疗方式。然而，它们往往效果不佳且不安全（会导致表皮萎缩）。因此，对替代疗法的研究仍在继续。
目的
评估补充抗氧化维生素（A、C、E）和矿物质（锌、硒）对白癜风治疗的有益效果。
方法
将40只5至12个月大、出现明显诱导性白癜风体征的实验性自身免疫性白癜风C57BL6小鼠依次随机分为五个平行组（每组8只小鼠）。给每组小鼠分配一个相同的预编码笼子。第一组（SZV）接受每千克饮食含ED + 1.4克锌（Zn）+ 0.04克硒（Se）+维生素（A 118国际单位、C 8.5毫克、E 5.4国际单位），第二组（PSZV）接受每千克饮食含ED + 1.4克锌（Zn）+ 0.04克硒（Se）+维生素（A 118国际单位、C 8.5毫克、E 5.4国际单位）+口服多酚，第三组（PSZ）接受每千克饮食含ED +由100克/升制备的绿茶汤（口服多酚）+ 1.4克锌 + 0.04克硒，第四组（P）接受每千克饮食含ED +由100克/升制备的绿茶汤，对照组5（C）接受每千克饮食含ED +蒸馏水。治愈定义为治疗部位重新色素沉着。在基线和每周都使用摄影和光学技术。
结果
到研究结束时，小鼠出现了明显的重新色素沉着。根据研究者的整体评估，70%的治疗小鼠有明确的重新色素沉着记录，治疗取得成功。
结论
我们的研究结果表明，补充抗氧化剂对治愈白癜风具有显著的有益效果，能显著提高临床疗效。
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