Kasiri Karam-Ali, Khoshdel Abolfazl, Karimi Afshin, Sedehi Morteza, Kasiri Niloufar
Department of Pediatrics, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Biochemistry Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
J Adv Pharm Technol Res. 2017 Apr-Jun;8(2):63-66. doi: 10.4103/japtr.JAPTR_162_16.
is an important risk factor for chronic gastritis, peptic ulcer, and gastric cancer. Three-drug regimen is the first-line treatment for this infection, but the response rate to treatment varies in different geographical regions. This study was conducted to comparatively determine the effect of amoxicillin and metronidazole on three-drug regimen to treat infection in 1-15-year-old children. This clinical trial was conducted on 82 patients aged 1-15 years with convenience sampling referring to the Endoscopy Unit of Hajar Hospital, Shahrekord. Group 1 was administered with clarithromycin, amoxicillin, and omeprazole (CAO), and Group 2 with, clarithromycin, metronidazole, and omeprazole (CMO). One month after completion of the treatment, stool antigen test was used to study the eradication of . Data were analyzed using SPSS software by Chi-square test. Three of the 82 patients were excluded from the study because of side effects caused by drugs. Nearly 87.2% of the patients in CAO-treated group and 92.5% in CMO-treated group had response to treatment. There was no significant difference in eradication rate between the two regimens ( = 0.43). The two regimens displayed no superiority over each other for eradicating infection and response rate to treatment in children aged 1-15 years.
是慢性胃炎、消化性溃疡和胃癌的重要危险因素。三联疗法是这种感染的一线治疗方法，但不同地理区域的治疗反应率有所不同。本研究旨在比较阿莫西林和甲硝唑对三联疗法治疗1至15岁儿童感染的效果。这项临床试验对82名年龄在1至15岁的患者进行了便利抽样，这些患者转诊至设拉子哈贾尔医院内镜科。第1组给予克拉霉素、阿莫西林和奥美拉唑（CAO），第2组给予克拉霉素、甲硝唑和奥美拉唑（CMO）。治疗完成后1个月，使用粪便抗原试验研究的根除情况。数据使用SPSS软件通过卡方检验进行分析。82名患者中有3名因药物副作用被排除在研究之外。CAO治疗组近87.2%的患者和CMO治疗组92.5%的患者对治疗有反应。两种治疗方案的根除率没有显著差异（=0.43）。在1至15岁儿童中，两种治疗方案在根除感染和治疗反应率方面均无优势。
