Salinas Sara, Junyent Felix, Coré Nathalie, Cremer Harold, Kremer Eric J
Université de Montpellier, Montpellier, France.
Pathogenesis and Control of Chronic Infections, Inserm UMR 1058, Montpellier, France.
Neurogenesis (Austin). 2017 Apr 27;4(1):e1304790. doi: 10.1080/23262133.2017.1304790. eCollection 2017.
The molecular and cellular basis of adult neurogenesis has attracted considerable attention for fundamental and clinical applications because neural stem cells and newborn neurons may, one day, be harnessed to replace neurons and allow cognitive improvement in the diseased brain. In rodents, neural progenitors are located in the dentate gyrus and the sub/periventricular zone. In the dentate gyrus the generation of newborn neurons is associated with plasticity, including regulation of memory. The role of subventricular zone neural precursors that migrate to the olfactory bulb is less characterized. Identifying factors that impact neural stem cell proliferation, migration and differentiation is therefore before we can harness their potential. Here, we expand upon our recent results showing that CAR, the coxsackievirus and adenovirus receptor, is among the developing list of key players when it comes to the complex process of integrating newborn neurons into existing circuits in the mature brain.
成体神经发生的分子和细胞基础因其在基础研究和临床应用方面的重要性而备受关注，因为神经干细胞和新生神经元未来有可能被用于替代受损神经元，从而改善患病大脑的认知功能。在啮齿动物中，神经祖细胞位于齿状回和室下区/脑室周围区域。在齿状回中，新生神经元的产生与可塑性相关，包括记忆调节。迁移至嗅球的脑室下区神经前体细胞的作用尚不清楚。因此，在我们能够利用神经干细胞的潜力之前，需要先确定影响其增殖、迁移和分化的因素。在此，我们进一步阐述了我们最近的研究结果，即柯萨奇病毒和腺病毒受体（CAR）在将新生神经元整合到成熟大脑现有神经回路这一复杂过程中，属于不断增加的关键因素之一。
