Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Key Laboratory of Analytical Science and Technology of Hebei Province, College of Chemistry and Environmental Science, Hebei University , Baoding 071002, Hebei, P. R. China.
ACS Appl Mater Interfaces. 2017 Jun 7;9(22):18512-18520. doi: 10.1021/acsami.7b03906. Epub 2017 May 26.
The emergence of drug-resistant bacteria severely challenges the antimicrobial agents and antibacterial strategy. Here, we demonstrate a novel, simple, and highly efficient combination therapy strategy by direct combinations of cationic conjugated polymers (CCPs) with polypeptide antibiotics against Gram-negative and Gram-positive bacteria based on a synergistic antibacterial effect. The combination therapy method enhances the antibacterial efficacy with a significantly reduced antibiotic dosage. Also, the highly efficient and synergistic killing of drug-resistant bacteria is realized. Using combinations of CCPs and antibiotics to show increased antibacterial activity, this strategy will provide a much wider scope of the discovery of efficient antibacterial systems than that of antibiotic-antibiotic combinations. The proposed combination therapy method provides a universal and powerful platform for the treatment of pathogens, in particular, the drug-resistant bacteria, and also opens a new way for the development of efficient antibacterial systems.
耐药菌的出现严重挑战了抗菌药物和抗菌策略。在这里，我们基于协同抗菌作用，展示了一种新颖、简单、高效的阳离子共轭聚合物（CCP）与多肽抗生素直接组合的针对革兰氏阴性菌和革兰氏阳性菌的新型联合治疗策略。联合治疗方法可通过显著减少抗生素剂量来提高抗菌功效。同时，实现了对耐药菌的高效协同杀伤。通过 CCP 与抗生素的组合显示出增强的抗菌活性，这种策略将为发现高效抗菌系统提供比抗生素-抗生素组合更广泛的范围。所提出的联合治疗方法为治疗病原体，特别是耐药菌提供了一个通用而强大的平台，也为开发高效抗菌系统开辟了新途径。
