新型精神活性物质的使用在双相情感障碍中比在精神障碍中更为常见：一项多中心观察性研究。

Novel psychoactive substance consumption is more represented in bipolar disorder than in psychotic disorders: A multicenter-observational study.

作者信息

Acciavatti Tiziano, Lupi Matteo, Santacroce Rita, Aguglia Andrea, Attademo Luigi, Bandini Laura, Ciambrone Paola, Lisi Giulia, Migliarese Giovanni, Pinna Federica, Quattrone Diego, Ribolsi Michele, Signorelli Maria Salvina, Calò Salvatore, Schifano Fabrizio, di Giannantonio Massimo, Martinotti Giovanni

机构信息

Department of Neuroscience and Imaging, "G. d'Annunzio" University, Chieti, Italy.

University of Turin, Turin, Italy.

出版信息

Hum Psychopharmacol. 2017 May;32(3). doi: 10.1002/hup.2578. Epub 2017 May 18.

DOI:10.1002/hup.2578

PMID:28517032

Abstract

OBJECTIVE

Comorbidities between psychiatric diseases and use of traditional substances of abuse are common. Nevertheless, there are few data regarding the use of novel psychoactive substances (NPS) among psychiatric patients. Aim of this multicentre survey is to investigate the consumption of a number of psychoactive substances in a young psychiatric sample.

METHODS

Between December 2013 and September 2015, a questionnaire was administered in 10 Italian psychiatric care facilities to a sample of 671 patients, aged 18-26 (mean age 22.24; SD 2.87).

RESULTS

About 8.2% of the sample declared to have used NPS at least once, and 2.2% had consumed NPS in the previous 3 months. The three psychiatric diagnoses most frequently associated with NPS use were bipolar disorder (23.1%), personality disorders (11.8%), and schizophrenia and related disorders (11.6%). In univariate regression analysis, bipolar disorder was positively associated with NPS consumption, an association that did not reach statistical significance in the multivariate analysis.

CONCLUSIONS

The use of NPS in a young psychiatric population appears to be frequent, and probably still underestimated. Bipolar disorder shows an association with NPS use. Careful and constant monitoring and an accurate evaluation of possible clinical effects related to NPS use are necessary.

摘要

目的

精神疾病与传统滥用物质之间的共病情况很常见。然而，关于精神科患者使用新型精神活性物质（NPS）的数据却很少。这项多中心调查的目的是调查一组年轻精神科样本中多种精神活性物质的使用情况。

方法

在2013年12月至2015年9月期间，对意大利10家精神科护理机构的671名年龄在18 - 26岁（平均年龄22.24岁；标准差2.87）的患者进行了问卷调查。

结果

约8.2%的样本宣称至少使用过一次NPS，2.2%的患者在过去3个月内使用过NPS。与使用NPS最常相关的三种精神科诊断是双相情感障碍（23.1%）、人格障碍（11.8%）以及精神分裂症和相关障碍（11.6%）。在单因素回归分析中，双相情感障碍与NPS使用呈正相关，但在多因素分析中这种关联未达到统计学意义。