近期的组学技术及其在个性化医疗中的新兴应用。
Recent omics technologies and their emerging applications for personalised medicine.
作者信息
Kim Dong-Hyuk, Kim Young-Sook, Son Nam-Il, Kang Chan-Koo, Kim Ah-Ram
机构信息
School of Life Science, Handong Global University, Pohang, Gyungbuk, 37554, South Korea.
出版信息
IET Syst Biol. 2017 Jun;11(3):87-98. doi: 10.1049/iet-syb.2016.0016.
Abstract
A major objective of 'omics' technologies is to understand genetic causality of complex traits of human diseases. High-throughput omics technologies and their application to medicine open up remarkable opportunities for realising optimised medical treatment for individuals. Because many major breakthrough and discoveries in this field have been driven by the development of new omics technologies, in this review, the authors aim to provide an in-depth description of their underlying principles as a foundation of developing another new omics technology, and to introduce their emerging applications for personalised medicine. The systems biology approach is then introduced as a future direction towards actionable personalised medicine.
摘要
“组学”技术的一个主要目标是了解人类疾病复杂性状的遗传因果关系。高通量组学技术及其在医学中的应用为实现针对个体的优化医疗带来了显著机遇。由于该领域的许多重大突破和发现都是由新的组学技术发展所推动的，在本综述中，作者旨在深入描述这些技术的基本原理，作为开发另一种新组学技术的基础，并介绍它们在个性化医疗中的新兴应用。随后引入系统生物学方法，作为实现可操作的个性化医疗的未来方向。
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