从子宫到坟墓的个体化医学。
Individualized medicine from prewomb to tomb.
机构信息
The Scripps Translational Science Institute, The Scripps Research Institute and Scripps Health, La Jolla, CA 92037, USA.
出版信息
Cell. 2014 Mar 27;157(1):241-53. doi: 10.1016/j.cell.2014.02.012.
Abstract
That each of us is truly biologically unique, extending to even monozygotic, "identical" twins, is not fully appreciated. Now that it is possible to perform a comprehensive "omic" assessment of an individual, including one's DNA and RNA sequence and at least some characterization of one's proteome, metabolome, microbiome, autoantibodies, and epigenome, it has become abundantly clear that each of us has truly one-of-a-kind biological content. Well beyond the allure of the matchless fingerprint or snowflake concept, these singular, individual data and information set up a remarkable and unprecedented opportunity to improve medical treatment and develop preventive strategies to preserve health.
摘要
我们每个人在生物学上都是独一无二的，甚至同卵双胞胎也不例外，这一点尚未被充分认识。现在，对个体进行全面的“组学”评估已成为可能，包括一个人的 DNA 和 RNA 序列，以及对其蛋白质组、代谢组、微生物组、自身抗体和表观基因组的至少一些特征描述，这充分表明我们每个人都拥有真正独一无二的生物学内容。这些独特的个体数据和信息超越了无与伦比的指纹或雪花概念的吸引力，为改善医疗和制定保护健康的预防策略提供了一个显著的、前所未有的机会。
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Sci Transl Med. 2013 Nov 27;5(213):213ra165. doi: 10.1126/scitranslmed.3007095.
2
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide.肠道微生物群调节环磷酰胺的抗癌免疫作用。
Science. 2013 Nov 22;342(6161):971-6. doi: 10.1126/science.1240537.
3
Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment.共生菌通过调节肿瘤微环境来控制癌症对治疗的反应。
Science. 2013 Nov 22;342(6161):967-70. doi: 10.1126/science.1240527.
4
Telltale hearts.
Nat Med. 2013 Nov;19(11):1361-4. doi: 10.1038/nm1113-1361.
5
Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing.基于大规模平行DNA测序的临床癌症基因组分析检测方法的开发与验证
Nat Biotechnol. 2013 Nov;31(11):1023-31. doi: 10.1038/nbt.2696. Epub 2013 Oct 20.
6
"N of 1" case reports in the era of whole-genome sequencing.全基因组测序时代的“n -of-1”病例报告。
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7
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8
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