The Scripps Translational Science Institute, The Scripps Research Institute and Scripps Health, La Jolla, CA 92037, USA.
Cell. 2014 Mar 27;157(1):241-53. doi: 10.1016/j.cell.2014.02.012.
That each of us is truly biologically unique, extending to even monozygotic, "identical" twins, is not fully appreciated. Now that it is possible to perform a comprehensive "omic" assessment of an individual, including one's DNA and RNA sequence and at least some characterization of one's proteome, metabolome, microbiome, autoantibodies, and epigenome, it has become abundantly clear that each of us has truly one-of-a-kind biological content. Well beyond the allure of the matchless fingerprint or snowflake concept, these singular, individual data and information set up a remarkable and unprecedented opportunity to improve medical treatment and develop preventive strategies to preserve health.
我们每个人在生物学上都是独一无二的，甚至同卵双胞胎也不例外，这一点尚未被充分认识。现在，对个体进行全面的“组学”评估已成为可能，包括一个人的 DNA 和 RNA 序列，以及对其蛋白质组、代谢组、微生物组、自身抗体和表观基因组的至少一些特征描述，这充分表明我们每个人都拥有真正独一无二的生物学内容。这些独特的个体数据和信息超越了无与伦比的指纹或雪花概念的吸引力，为改善医疗和制定保护健康的预防策略提供了一个显著的、前所未有的机会。
