Singh Siddharth
Division of Gastroenterology, University of California San Diego, La Jolla, California, USA.
Division of Biomedical Informatics, University of California San Diego, La Jolla, California, USA.
Clin Transl Gastroenterol. 2017 May 18;8(5):e93. doi: 10.1038/ctg.2017.20.
Systematic reviews with or without meta-analyses serve a key purpose in critically and objectively synthesizing all available evidence regarding a focused clinical question and can inform clinical practice and clinical guidelines. Performing a rigorous systematic review is multi-step process, which includes (a) identifying a well-defined focused clinically relevant question, (b) developing a detailed review protocol with strict inclusion and exclusion criteria, (c) systematic literature search of multiple databases and unpublished data, in consultation with a medical librarian, (d) meticulous study identification and (e) systematic data abstraction, by at least two sets of investigators independently, (f) risk of bias assessment, and (g) thoughtful quantitative synthesis through meta-analysis where relevant. Besides informing guidelines, credible systematic reviews and quality of evidence assessment can help identify key knowledge gaps for future studies.
无论是否进行荟萃分析，系统评价在批判性和客观地综合有关特定临床问题的所有现有证据方面都起着关键作用，可为临床实践和临床指南提供参考。进行严格的系统评价是一个多步骤过程，包括：（a）确定一个定义明确的、聚焦于临床相关的问题；（b）制定一份详细的评价方案，明确严格的纳入和排除标准；（c）与医学图书馆员协商，对多个数据库和未发表的数据进行系统的文献检索；（d）细致的研究识别；（e）至少两组研究人员独立进行系统的数据提取；（f）偏倚风险评估；以及（g）在相关情况下通过荟萃分析进行深入的定量综合。除了为指南提供参考外，可靠的系统评价和证据质量评估有助于识别未来研究的关键知识空白。
