Chaturvedi Pankaj, Tyagi Suresh C
Department of Physiology, University of Louisville, Louisville, Kentucky.
J Cell Physiol. 2018 Mar;233(3):1895-1896. doi: 10.1002/jcp.26014. Epub 2017 Jul 7.
In the past decade, NAD+ has gained importance for its beneficial effects as antioxidant and anti-aging molecule. A paper in science by Zhang et al. () has described that NAD+ when replenished, ameliorates muscle dystrophy in mice by improving mitochondrial function. NAD+ was also demonstrated by the authors to improve the life span of mice. Cox et al. () demonstrated the cardiac effects of NAD+ which mitigated chronic heart failure via mitochondrial redox state mechanism. Cox et al. () also demonstrated that NAD+ is provided in the drinking water, it improves cardiac relaxation in volume overload model of heart failure. Although NAD+ has a profound anti-aging and anti-oxidant effects, its effect on humans and use as a dietary supplement needs more exploration.
在过去十年中，NAD+因其作为抗氧化和抗衰老分子的有益作用而变得重要。张等人发表在《科学》杂志上的一篇论文描述，补充NAD+可通过改善线粒体功能来改善小鼠的肌肉萎缩症。作者还证明NAD+可延长小鼠寿命。考克斯等人证明了NAD+对心脏的作用，即通过线粒体氧化还原状态机制减轻慢性心力衰竭。考克斯等人还证明，在饮用水中添加NAD+，可改善心力衰竭容量超负荷模型中的心脏舒张功能。尽管NAD+具有显著的抗衰老和抗氧化作用，但其对人类的影响以及作为膳食补充剂的用途仍需更多探索。
