Suter S, Chevallier I
Department of Pediatrics, University Children's Hospital, Geneva.
Biol Chem Hoppe Seyler. 1988 Jul;369(7):573-8. doi: 10.1515/bchm3.1988.369.2.573.
Eglin C is an inhibitor of polymorphonuclear leukocyte elastase and cathepsin G. Recently, it was suggested that Eglin C may inhibit bacterial clearance in an experimental animal model of pneumonia. Since the phagocytic-bactericidal activity of polymorphonuclear leukocytes is most important in the promotion of bacterial clearance, we determined the effect of Eglin C on a variety of functions of isolated human polymorphonuclear leukocytes such as phagocytic-bactericidal activity, superoxide production, degranulation and chemotaxis. Apart from a partial inhibition of superoxide production, which was shown to be due to a superoxide dismutase-like effect of Eglin C, there was no inhibition of polymorphonuclear leukocyte functions measured. Eglin C can therefore be considered as a protease inhibitor, which does not interfere with the phagocytic-bactericidal activity of human polymorphonuclear leukocytes.
艾格林C是一种多形核白细胞弹性蛋白酶和组织蛋白酶G的抑制剂。最近，有人提出艾格林C可能在肺炎实验动物模型中抑制细菌清除。由于多形核白细胞的吞噬杀菌活性在促进细菌清除方面最为重要，我们测定了艾格林C对分离的人多形核白细胞多种功能的影响，如吞噬杀菌活性、超氧化物产生、脱颗粒和趋化性。除了对超氧化物产生有部分抑制作用（已证明这是由于艾格林C具有超氧化物歧化酶样效应）外，所测定的多形核白细胞功能均未受到抑制。因此，艾格林C可被视为一种蛋白酶抑制剂，它不会干扰人多形核白细胞的吞噬杀菌活性。
