Mini E, Novelli A, Coronnello M, Fallani S, Pesciullesi A, Periti P
Dipartimento di Farmacologia, Università degli Studi, Firenze, Italy.
J Chemother. 1993 Dec;5(6):499-501.
The in vitro effects of brodimoprim and trimethoprim on the functions of human polymorphonuclear (PMN) leukocytes have been studied comparatively evaluating chemotaxis, phagocytosis and production of superoxide anion. No significant effects of both diaminopyrimidines on chemotaxis and phagocytic activity of PMNs have been observed while both brodimoprim and trimethoprim enhanced the oxidative burst. A synergistic activity between the host immune system and the direct antimicrobial action of brodimoprim may occur while using this diaminopyrimidine in vivo.
已比较研究了溴莫普明和甲氧苄啶对人多形核（PMN）白细胞功能的体外作用，评估了趋化性、吞噬作用和超氧阴离子的产生。未观察到这两种二氨基嘧啶对PMN趋化性和吞噬活性有显著影响，而溴莫普明和甲氧苄啶均增强了氧化爆发。在体内使用这种二氨基嘧啶时，宿主免疫系统与溴莫普明的直接抗菌作用之间可能会发生协同活性。
