Goodman Sherryl H, Rouse Matthew H, Long Qi, Ji Shuang, Brand Sarah R
Emory University.
Infant Ment Health J. 2011 May;32(3):339-361. doi: 10.1002/imhj.20300.
This prospective study examined the variability within clinical characteristics of antenatal maternal depression and cortisol levels for associations with newborn infant behavior using the Neonatal Behavioral Assessment Scale (NBAS; T.B. Brazelton, 1984). Participants were 81 pregnant women at risk for perinatal depression given their histories of depression prior to pregnancy. We took into consideration not only whether the woman experienced antenatal depression but also whether the depression met diagnostic criteria and variability in timing (onset and occurrence) of antenatal depression and symptom severity. Infants of mothers who became depressed during pregnancy scored less optimally on a subset of the NBAS scales, specifically those scales related to infant neuroregulation. Among the clinical characteristics of depression, the fetus' overall exposure to mothers' depression (reflected in the mean) was most often and most strongly associated with NBAS scales. In terms of timing, third-trimester exposure was significantly related to newborn behavior. The findings are discussed within the S.H. Goodman and I.H. Gotlib (1999) model for transmission of psychopathology to offspring of depressed mothers.
这项前瞻性研究使用新生儿行为评估量表（NBAS；T.B. 布拉泽尔顿，1984年），考察了产前母亲抑郁的临床特征和皮质醇水平的变异性与新生儿行为之间的关联。研究参与者为81名有围产期抑郁风险的孕妇，她们在怀孕前有抑郁病史。我们不仅考虑了女性是否经历产前抑郁，还考虑了抑郁是否符合诊断标准、产前抑郁的时间变异性（发作和发生时间）以及症状严重程度。孕期出现抑郁的母亲所生的婴儿在NBAS量表的一个子集中得分不太理想，特别是那些与婴儿神经调节相关的量表。在抑郁的临床特征中，胎儿对母亲抑郁的总体暴露（以平均值反映）最常且最强地与NBAS量表相关。在时间方面，孕晚期暴露与新生儿行为显著相关。研究结果将在S.H. 古德曼和I.H. 戈特利布（1999年）关于精神病理学向抑郁母亲后代传递的模型中进行讨论。
