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SIRT3 as a regulator of hepatic autophagy.SIRT3作为肝脏自噬的调节因子。
Hepatology. 2017 Sep;66(3):700-702. doi: 10.1002/hep.29271. Epub 2017 Jul 20.
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Autophagy maintains ubiquitination-proteasomal degradation of Sirt3 to limit oxidative stress in K562 leukemia cells.自噬维持Sirt3的泛素化-蛋白酶体降解以限制K562白血病细胞中的氧化应激。
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Mesenchymal Stem Cells Attenuate Diabetic Lung Fibrosis via Adjusting Sirt3-Mediated Stress Responses in Rats.间质干细胞通过调节大鼠 Sirt3 介导的应激反应减轻糖尿病肺纤维化。
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Mechanisms and disease implications of sirtuin-mediated autophagic regulation.沉默调节蛋白介导的自噬调节的机制及疾病影响
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Genipin alleviates vascular hyperpermeability following hemorrhagic shock by up-regulation of SIRT3/autophagy.京尼平通过上调SIRT3/自噬减轻失血性休克后的血管通透性增加。
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本文引用的文献

1
Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicity.沉默调节蛋白3作为自噬的负调节因子，决定肝细胞对脂毒性的易感性。
Hepatology. 2017 Sep;66(3):936-952. doi: 10.1002/hep.29229. Epub 2017 Jul 20.
2
Sirt3 deficiency exacerbates diabetic cardiac dysfunction: Role of Foxo3A-Parkin-mediated mitophagy.Sirt3 缺乏加剧糖尿病性心脏功能障碍：Foxo3A-Parkin 介导的线粒体自噬的作用。
Biochim Biophys Acta Mol Basis Dis. 2017 Aug;1863(8):1973-1983. doi: 10.1016/j.bbadis.2016.10.021. Epub 2016 Oct 26.
3
Regulation of Liver Metabolism by Autophagy.自噬对肝脏代谢的调节
Gastroenterology. 2016 Feb;150(2):328-39. doi: 10.1053/j.gastro.2015.09.042. Epub 2015 Oct 8.
4
SirT3 regulates the mitochondrial unfolded protein response.SirT3 调控线粒体未折叠蛋白反应。
Mol Cell Biol. 2014 Feb;34(4):699-710. doi: 10.1128/MCB.01337-13. Epub 2013 Dec 9.
5
SIRT3: as simple as it seems?SIRT3：就像看上去那么简单？
Gerontology. 2014;60(1):56-64. doi: 10.1159/000354382. Epub 2013 Oct 25.
6
Restricted mitochondrial protein acetylation initiates mitochondrial autophagy.受限的线粒体蛋白乙酰化启动线粒体自噬。
J Cell Sci. 2013 Nov 1;126(Pt 21):4843-9. doi: 10.1242/jcs.131300. Epub 2013 Sep 4.
7
Sirtuins' modulation of autophagy.Sirtuins 对自噬的调节作用。
J Cell Physiol. 2013 Dec;228(12):2262-70. doi: 10.1002/jcp.24399.
8
Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis.肌肉或肝脏特异性 Sirt3 缺乏会导致线粒体蛋白过度乙酰化，而不影响整体代谢平衡。
Sci Rep. 2012;2:425. doi: 10.1038/srep00425. Epub 2012 May 28.
9
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.SIRT3 缺失和线粒体蛋白乙酰化过度加速代谢综合征的发展。
Mol Cell. 2011 Oct 21;44(2):177-90. doi: 10.1016/j.molcel.2011.07.019.
10
Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation.脂肪肝与 SIRT3 活性降低和线粒体蛋白乙酰化过度有关。
Biochem J. 2011 Feb 1;433(3):505-14. doi: 10.1042/BJ20100791.

SIRT3 as a regulator of hepatic autophagy.

作者信息

Cho Chun-Seok, Lombard David B, Lee Jun Hee

机构信息

Department of Molecular and Integrative Physiology, Michigan Medicine, University of Michigan, Ann Arbor, MI.

Department of Pathology, Michigan Medicine, University of Michigan, Ann Arbor, MI.

出版信息

Hepatology. 2017 Sep;66(3):700-702. doi: 10.1002/hep.29271. Epub 2017 Jul 20.

DOI:10.1002/hep.29271
PMID:28520180
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5570665/
Abstract
摘要