Center for Bioengineering and Nanomedicine, Faculty of Dentistry, Division of Health Sciences, University of Otago, Dunedin, New Zealand.
Neurochem Int. 2021 Jun;146:105034. doi: 10.1016/j.neuint.2021.105034. Epub 2021 Mar 28.
Biomaterials is an emerging field in the study of brain tissue engineering and repair or neurogenesis. The fabrication of biomaterials that can replicate the mechanical and viscoelastic features required by the brain, including the poroviscoelastic responses, force dissipation, and solute diffusivity are essential to be mapped from the macro to the nanoscale level under physiological conditions in order for us to gain an effective treatment for neurodegenerative diseases. This research topic has identified a critical study gap that must be addressed, and that is to source suitable biomaterials and/or create reliable brain-tissue-like biomaterials. This chapter will define and discuss the various types of biomaterials, their structures, and their function-properties features which would enable the development of next-generation biomaterials useful in brain repair.
生物材料是脑组织工程和修复或神经发生研究中的一个新兴领域。制造能够复制大脑所需的机械和黏弹性特征的生物材料至关重要，包括多孔黏弹性响应、力耗散和溶质扩散性，以便在生理条件下从宏观到纳米尺度进行映射，从而为神经退行性疾病提供有效的治疗方法。本研究课题确定了一个必须解决的关键研究空白，即寻找合适的生物材料和/或创建可靠的类脑组织生物材料。本章将定义和讨论各种类型的生物材料、它们的结构以及它们的功能特性，这些特性将使下一代有用的生物材料在大脑修复中得到发展。
