Polymers and Composite Materials Group (GMPC), Department of Chemistry, State University of Maringá (UEM), Av. Colombo 5790, CEP 87020-900 Maringá, Paraná, Brazil.
Stereochemistry of Organic Compounds and Docking Molecular (ECO-DM), Brazil.
Carbohydr Polym. 2017 Aug 15;170:99-106. doi: 10.1016/j.carbpol.2017.04.073. Epub 2017 Apr 25.
[Hmim][HSO] ionic liquid (IL) and bio-renewable sources as chitosan (CHT) and chondroitin sulfate (CS) were used to yield hydrogel-based materials (CHT/CS). The use of IL to solubilize both polysaccharides was considered an innovative way based on "green chemistry" principle, aiming the production of CHT/CS blended systems. CHT/CS hydrogels were carried out in homogeneous medium from short dissolution times. The hydrogels were characterized and achieved with excellent stabilities (in the 1.2-10pH range), larger swelling capacities, as well as devoid of cytotoxicity towards the normal VERO and diseased HT29 cells. The CHT/CS hydrogels carried out in [Hmim][HSO] could be applied in many technological purposes, like medical, pharmaceutical, and environmental fields.
[Hmim][HSO] 离子液体 (IL) 和生物可再生资源（如壳聚糖 (CHT) 和硫酸软骨素 (CS)）被用于生成水凝胶基材料 (CHT/CS)。使用 IL 溶解两种多糖被认为是一种基于“绿色化学”原则的创新方法，旨在生产 CHT/CS 共混体系。CHT/CS 水凝胶在短溶解时间的均相介质中进行。对水凝胶进行了表征，结果表明其具有优异的稳定性（在 1.2-10pH 范围内）、更大的溶胀能力，并且对正常 VERO 和患病 HT29 细胞均无细胞毒性。在 [Hmim][HSO] 中进行的 CHT/CS 水凝胶可应用于许多技术领域，如医疗、制药和环境领域。
