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本文引用的文献

1
Fecal biomarkers in inflammatory bowel disease.炎症性肠病中的粪便生物标志物。
J Gastroenterol Hepatol. 2017 Mar;32(3):577-582. doi: 10.1111/jgh.13611.
2
Determination of faecal inflammatory marker concentration as a noninvasive method of evaluation of pathological activity in children with inflammatory bowel diseases.测定粪便炎症标志物浓度作为评估炎症性肠病患儿病理活动的一种非侵入性方法。
Adv Med Sci. 2015 Sep;60(2):246-52. doi: 10.1016/j.advms.2015.04.003. Epub 2015 Apr 29.
3
MicroRNAs in inflammatory bowel diseases: paradoxes and possibilities.炎症性肠病中的微小RNA:矛盾与可能性
Inflamm Bowel Dis. 2015 May;21(5):1160-5. doi: 10.1097/MIB.0000000000000288.
4
The diagnostic value of a new fecal marker, matrix metalloprotease-9, in different types of inflammatory bowel diseases.新型粪便标志物基质金属蛋白酶-9在不同类型炎症性肠病中的诊断价值。
J Crohns Colitis. 2015 Mar;9(3):231-7. doi: 10.1093/ecco-jcc/jjv005. Epub 2015 Jan 12.
5
Role of HMGB1 as a suitable biomarker of subclinical intestinal inflammation and mucosal healing in patients with inflammatory bowel disease.HMGB1作为炎症性肠病患者亚临床肠道炎症和黏膜愈合的合适生物标志物的作用。
Inflamm Bowel Dis. 2014 Aug;20(8):1448-57. doi: 10.1097/MIB.0000000000000113.
6
Pyruvate kinase M2 regulates apoptosis of intestinal epithelial cells in Crohn's disease.丙酮酸激酶 M2 调节克罗恩病中肠上皮细胞的凋亡。
Dig Dis Sci. 2015 Feb;60(2):393-404. doi: 10.1007/s10620-014-3189-0. Epub 2014 May 11.
7
Comparison of fecal pyruvate kinase isoform M2 and calprotectin in assessment of pediatric inflammatory bowel disease severity and activity.粪便丙酮酸激酶同工酶M2与钙卫蛋白在评估小儿炎症性肠病严重程度及活动度中的比较
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8
Metalloproteinase-3 and -9 as novel markers in the evaluation of ulcerative colitis activity in children.金属蛋白酶-3 和 -9 作为评估儿童溃疡性结肠炎活动的新型标志物。
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9
Fecal calprotectin, MMP-9, and human beta-defensin-2 levels in pediatric inflammatory bowel disease.粪便钙卫蛋白、MMP-9 和人β-防御素-2 在小儿炎症性肠病中的水平。
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新型生物标志物与生物标志物在炎症性肠病中的未来潜力

Novel Biomarkers and the Future Potential of Biomarkers in Inflammatory Bowel Disease.

作者信息

Duvoisin Gilles, Lopez Robert N, Day Andrew S, Lemberg Daniel A, Gearry Richard B, Leach Steven T

机构信息

Department of Paediatrics, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Department of Gastroenterology, Sydney Children's Hospital Randwick, Sydney, Australia.

出版信息

Mediators Inflamm. 2017;2017:1936315. doi: 10.1155/2017/1936315. Epub 2017 Apr 16.

DOI:10.1155/2017/1936315
PMID:28522897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5410373/
Abstract

There is increasing importance placed upon noninvasive assessment of gut inflammation. These tools are likely to be the key in differentiating intestinal inflammatory disease from functional disorders and in monitoring the response to intervention in individuals with known inflammatory conditions. Although various noninvasive markers are currently available, they have limitations and do not provide ideal utility. This review focuses on emerging markers of gut inflammation, highlighting the potential of specific markers.

摘要

肠道炎症的非侵入性评估正变得越来越重要。这些工具可能是区分肠道炎症性疾病与功能性疾病以及监测已知炎症状态个体对干预反应的关键。尽管目前有多种非侵入性标志物可用,但它们存在局限性,无法提供理想的效用。本综述重点关注肠道炎症的新兴标志物,突出特定标志物的潜力。