香芪方对胃肠动力的影响。
Effects of Chinese herbal medicine Xiangbin prescription on gastrointestinal motility.
机构信息
Zhi Jiang, Li-Xing Cao, Bo Liu, Qi-Cheng Chen, Wen-Fan Shang, Dan-Yan Li, Zhi-Qiang Chen, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, Guangdong Province, China.
出版信息
World J Gastroenterol. 2017 Apr 28;23(16):2987-2994. doi: 10.3748/wjg.v23.i16.2987.
AIM
To investigate the effects of Xiangbin prescription (XBP), a Chinese herbal concoction, on gastrointestinal motility.
METHODS
Forty healthy volunteers were recruited for this randomized controlled trial of XBP. Antroduodenojejunal manometry was used to monitor gastrointestinal motility in these subjects. After the subjects had fasted for at least 12 h, XBP ( = 30) or placebo ( = 10) was orally administrated and gastrointestinal motility was recorded for 4 h. Plasma motilin and ghrelin were measured by enzyme-linked immunosorbent assay.
RESULTS
Oral administration of XBP significantly increased the amplitude of duodenal contractions [19.5 (13.0-26.7) 16.9 (12.3-23.9), < 0.05], jejunal contractions [18.3 (15.3-25.0) 15.4 (11.7-23.9), < 0.01], and the motility index of duodenal contractions [522.0 (146.0-139.0) 281.0 (76.5-1006.0), < 0.01] in phase II of the migratory motor complex (MMC), which subsequently initiated the MMC cycle [74.0 (30.0-118.0) 116.5 (24.0-219.0), < 0.05], shortened the duration of phase I of the MMC [42.0 (0.0-90.0) 111.5 (42.0-171.0), < 0.01], and lengthened the duration of phase II of the MMC [120 (21-240) 58 (16-170), < 0.01] compared to the duration before XBP administration. There were significant differences in the amplitude of jejunal contractions [19.8 (14.0-30.0) 18.0 (13.0-28.5), < 0.05], the motility index of duodenal contractions [236.0 (115.0-306.0) 195.0 (109.0-310.0), < 0.05)], and jejunal contractions [214.0 (95.0-403.0) 178.0 (55.0-304.0), < 0.01] in phase III of the MMC. Oral administration of XBP greatly increased plasma motilin (57.69 ± 9.03 49.38 ± 8.63, < 0.01) and ghrelin (279.20 ± 104.31 238.73 ± 115.59, < 0.01) concentrations compared to concentrations after oral administration of the placebo.
CONCLUSION
XBP can stimulate duodenal and jejunal motility and increase the concentrations of plasma motilin and ghrelin. The clinical applicability of XBP in treating GDIM deserves investigation.
目的
研究香芪方（XBP）对胃肠动力的影响。
方法
本研究采用随机对照试验，纳入 40 名健康志愿者，给予 XBP（n=30）或安慰剂（n=10）口服，观察 4 h 胃肠动力变化。采用抗蠕动十二指肠空肠测压法监测胃肠动力。志愿者空腹至少 12 h 后，口服 XBP 或安慰剂，记录 4 h 胃肠动力变化，采用酶联免疫吸附法检测血浆胃动素和 ghrelin 浓度。
结果
与用药前相比，XBP 可显著增加十二指肠收缩幅度[19.5（13.0-26.7） 16.9（12.3-23.9）， < 0.05]、空肠收缩幅度[18.3（15.3-25.0） 15.4（11.7-23.9）， < 0.01]和十二指肠收缩的运动指数[522.0（146.0-139.0） 281.0（76.5-1006.0）， < 0.01]，这可引发移行性运动复合波（MMC）Ⅱ相，进而启动 MMC 周期[74.0（30.0-118.0） 116.5（24.0-219.0）， < 0.05]，缩短 MMC Ⅰ相持续时间[42.0（0.0-90.0） 111.5（42.0-171.0）， < 0.01]，延长 MMC Ⅱ相持续时间[120（21-240） 58（16-170）， < 0.01]。与安慰剂相比，XBP 还可显著增加 MMC Ⅲ相空肠收缩幅度[19.8（14.0-30.0） 18.0（13.0-28.5）， < 0.05]、十二指肠收缩的运动指数[236.0（115.0-306.0） 195.0（109.0-310.0）， < 0.05]和空肠收缩[214.0（95.0-403.0） 178.0（55.0-304.0）， < 0.01]，并显著增加血浆胃动素（57.69 ± 9.03 49.38 ± 8.63， < 0.01）和 ghrelin（279.20 ± 104.31 238.73 ± 115.59， < 0.01）浓度。
结论
XBP 可刺激十二指肠和空肠运动，增加血浆胃动素和 ghrelin 浓度。XBP 治疗 GDIM 的临床应用价值值得进一步研究。
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