帕金森病患者的诱发电位变化。
Evoked potential changes in patients with Parkinson's disease.
机构信息
Department of Neurology Zhoushan Hospital Wenzhou Medical University Zhoushan China.
出版信息
Brain Behav. 2017 Apr 7;7(5):e00703. doi: 10.1002/brb3.703. eCollection 2017 May.
OBJECTIVE
Patients with Parkinson's disease (PD) may have sensory dysfunction, and it can be more easily demonstrated through electrophysiologic testing. We aimed to explore whether the impairment of brainstem visual and auditory passageway exists in PD patients using visual evoked potential (VEP) and brainstem auditory evoked potential (BAEP) examinations.
METHODS
Forty-two PD cases and thirty controls participated in the study. All subjects underwent the VEP and BAEP examinations. The N75, P100, N145 latencies and P100 amplitude of VEP, the latencies of waves I, III, V and the interpeak latencies (IPL) of waves I-III, III-V, I-V were measured.
RESULTS
The N75, P100, N145 latencies of VEP, but not the amplitude of P100, were significantly longer in patients with PD than the control group (<.05). The latencies of wave III and wave V, the IPL of III-V and I-V were all significantly increased compared with control subjects while no significant difference was noted in waves I and I-III IPL.
CONCLUSION
Our results found that brainstem visual and auditory passageway may be impaired in PD patients.
SIGNIFICANCE
VEP and BAEP can be served as sensitive measurements in helping prognosis and assessment the severity of the disease.
目的
帕金森病（PD）患者可能存在感觉功能障碍，通过电生理测试可以更易证实。我们旨在通过视觉诱发电位（VEP）和脑干听觉诱发电位（BAEP）检查来探索 PD 患者是否存在脑干视觉和听觉通路的损伤。
方法
42 例 PD 患者和 30 例对照者参与了本研究。所有受试者均进行了 VEP 和 BAEP 检查。测量 VEP 的 N75、P100、N145 潜伏期和 P100 振幅，波 I、III、V 的潜伏期以及波 I-III、III-V、I-V 的峰间潜伏期（IPL）。
结果
PD 患者的 VEP 的 N75、P100、N145 潜伏期较对照组显著延长（P<.05），但 P100 波幅无显著差异。与对照组相比，波 III 和波 V 的潜伏期、III-V 和 I-V 的 IPL 均显著增加，而波 I 和 I-III IPL 无显著差异。
结论
我们的结果发现 PD 患者的脑干视觉和听觉通路可能受损。
意义
VEP 和 BAEP 可作为帮助预后和评估疾病严重程度的敏感测量方法。
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