Bara Tivadar, Gurzu Simona, Sugimura Haruhiko, Bara Tivadar, Beleaua Marius Alexandru, Jung Ioan
Department of Pathology, University of Medicine and Pharmacy of Tirgu Mures, Romania;
Rom J Morphol Embryol. 2017;58(1):41-44.
Aristolochic acid (AA) is a bioactive component of Chinese herbs, dietary supplements, slimming pills and contaminated flour, which is known to induce chronic tubulointerstitial disease. AA is also shown to be involved in the genesis of the upper urinary tract urothelial carcinoma (UTUC) and some other cancers, but its tumorigenic role is far to be understood. We performed a systematic literature review regarding the involvement of AA in malignant processes and molecular pathways of carcinogenesis. Twenty representative papers were selected for this review. These papers reveal that AA exposure increases the risk for UTUC, renal cell carcinoma, hepatocellular carcinoma, gastric and small intestine cancer. The role of AA in lymphomagenesis is also proposed. The A:T to T:A transversions occurring in the 5'-CpApG-3' trinucleotide context of the TP53 gene is considered to be the signature mutation of AA. Genes including H-ras, FGFR3, N-ras and BRCA2 are also involved. For further understanding of AA's role in tumorigenesis, the exploration of the AA's molecular signature is necessary.
马兜铃酸（AA）是中草药、膳食补充剂、减肥药和受污染面粉中的一种生物活性成分，已知其可诱发慢性肾小管间质性疾病。研究还表明，AA与上尿路尿路上皮癌（UTUC）及其他一些癌症的发生有关，但其致癌作用仍远未明确。我们对AA在恶性肿瘤发生过程及致癌分子途径中的作用进行了系统的文献综述。为此综述挑选了20篇具有代表性的论文。这些论文表明，接触AA会增加患UTUC、肾细胞癌、肝细胞癌、胃癌和小肠癌的风险。文中还提出了AA在淋巴瘤发生中的作用。发生在TP53基因5'-CpApG-3'三核苷酸序列中的A:T到T:A颠换被认为是AA的特征性突变。H-ras、FGFR3、N-ras和BRCA2等基因也参与其中。为进一步了解AA在肿瘤发生中的作用，有必要探索AA的分子特征。
