Tahiri Zejdush, Kellici Suela, Mone Iris, Shabani Driton, Qazimi Musa, Burazeri Genc
Faculty of Medicine, University of Medicine, Rr "Dibres", No. 371, Tirana, Albania.
Principal Family Medicine Center, St. Avdulla Tahiri, 60000, Gjilan, Kosovo.
Int J Clin Pharm. 2017 Aug;39(4):669-673. doi: 10.1007/s11096-017-0486-7. Epub 2017 May 18.
In post-war Kosovo, the magnitude of inappropriate use of benzodiazepines is unknown to date.
The aim of this study was to assess the prevalence and correlates of continuation of intake of benzodiazepines beyond prescription (referred to as "inappropriate use") in the adult population of Gjilan region in Kosovo.
A cross-sectional study was conducted in Gjilan region in 2015 including a representative sample of 780 individuals attending different pharmacies and reporting use of benzodiazepines (385 men and 395 women; age range 18-87 years; response rate: 90%). A structured questionnaire was administered to all participants inquiring about the use of benzodiazepines and socio-demographic characteristics.
Overall, the prevalence of inappropriate use of benzodiazepines was 58%. In multivariable-adjusted models, inappropriate use of benzodiazepines was significantly associated with older age (OR 1.7, 95% CI 1.1-2.7), middle education (OR 1.8, 95% CI 1.2-2.7), daily use (OR 1.4, 95% CI 1.1-2.0) and addiction awareness (OR 2.7, 95% CI 2.0-3.8). Furthermore, there was evidence of a borderline relationship with rural residence (OR 1.2, 95% CI 0.9-1.7).
Our study provides novel evidence about the prevalence and selected correlates of inappropriate use of benzodiazepines in Gjilan region of Kosovo. Health professionals and policymakers in Kosovo should be aware of the magnitude and determinants of drug misuse in this transitional society.
在战后的科索沃,苯二氮䓬类药物不当使用的规模至今尚不清楚。
本研究旨在评估科索沃吉兰地区成年人群中苯二氮䓬类药物超出处方继续服用(称为“不当使用”)的患病率及其相关因素。
2015年在吉兰地区进行了一项横断面研究,纳入了780名到不同药房购药并报告使用过苯二氮䓬类药物的个体作为代表性样本(385名男性和395名女性;年龄范围18 - 87岁;应答率:90%)。对所有参与者发放结构化问卷,询问其苯二氮䓬类药物的使用情况和社会人口学特征。
总体而言,苯二氮䓬类药物不当使用的患病率为58%。在多变量调整模型中,苯二氮䓬类药物的不当使用与年龄较大(比值比1.7,95%置信区间1.1 - 2.7)、中等教育程度(比值比1.8,95%置信区间1.2 - 2.7)、每日使用(比值比1.4,95%置信区间1.1 - 2.0)以及成瘾意识(比值比2.7,95%置信区间2.0 - 3.8)显著相关。此外,有证据表明与农村居住存在临界关系(比值比1.2,95%置信区间0.9 - 1.7)。
我们的研究提供了关于科索沃吉兰地区苯二氮䓬类药物不当使用的患病率及选定相关因素的新证据。科索沃的卫生专业人员和政策制定者应意识到这个转型社会中药物滥用的规模和决定因素。