精神分裂症中的组蛋白翻译后修饰

Histone Posttranslational Modifications in Schizophrenia.

作者信息

Thomas Elizabeth A

机构信息

Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, 10550 N. Torrey Pines Rd, SP2030, La Jolla, CA, 92037, USA.

出版信息

Adv Exp Med Biol. 2017;978:237-254. doi: 10.1007/978-3-319-53889-1_13.

DOI:10.1007/978-3-319-53889-1_13

PMID:28523550

Abstract

Schizophrenia is a complex neuropsychiatric disorder with high heritability; however, family and twin studies have indicated that environmental factors also play important roles in the etiology of disease. Environmental triggers exert their influence on behavior via epigenetic mechanisms. Epigenetic modifications, such as histone acetylation and methylation, as well as DNA methylation, can induce lasting changes in gene expression and have therefore been implicated in promoting the behavioral and neuronal behaviors that characterize this disorder. Importantly, because epigenetic processes are potentially reversible, they might serve as targets in the design of novel therapies in psychiatry. This chapter will review the current information regarding histone modifications in schizophrenia and the potential therapeutic relevance of such marks.

摘要

精神分裂症是一种具有高遗传性的复杂神经精神障碍；然而，家族和双胞胎研究表明环境因素在该疾病的病因学中也起着重要作用。环境触发因素通过表观遗传机制对行为产生影响。表观遗传修饰，如组蛋白乙酰化和甲基化以及DNA甲基化，可诱导基因表达的持久变化，因此与促进该疾病特征性的行为和神经行为有关。重要的是，由于表观遗传过程可能是可逆的，它们可能成为精神病学新疗法设计的靶点。本章将综述有关精神分裂症中组蛋白修饰的当前信息以及此类标记的潜在治疗相关性。