State Key Laboratory of Crop Stress Biology for Arid Areas and NWAFU-Purdue Joint Research Center, College of Plant Protection, Northwest A&F University, Yangling, 712100, Shaanxi, China.
Department of Botany and Plant Pathology, Purdue University, West Lafayette, IN, 47907, USA.
Curr Genet. 2021 Aug;67(4):535-538. doi: 10.1007/s00294-021-01167-2. Epub 2021 Feb 28.
The histone modifications usually form complicated networks to regulate accessibility of DNA and transcription. Identification of proteins that are involved in the crosstalk among different histone modifications will help to better understand the epigenetic regulatory network in eukaryotes. The Inhibitor of Growth (ING) proteins represent a tumor suppressor family were first linked to histone modification in yeast and their functions in epigenetic regulation were further characterized. This review summarizes the crosstalk of histone modification in fungi and describes recently achieved mechanistic insights into the role of Fng1 (an ING protein in filamentous ascomycetes) in this process. We conclude that Fng1 is involved in crosstalk among histone acetylation, deacetylation and methylation.
组蛋白修饰通常形成复杂的网络来调节 DNA 的可及性和转录。鉴定参与不同组蛋白修饰之间相互作用的蛋白质将有助于更好地理解真核生物中的表观遗传调控网络。生长抑制因子（ING）蛋白代表一个肿瘤抑制因子家族，它们最初与酵母中的组蛋白修饰有关，其在表观遗传调控中的功能进一步得到了表征。本综述总结了真菌中组蛋白修饰的相互作用，并描述了最近在丝状子囊菌中 Fng1（ING 蛋白）在这一过程中的作用机制方面的研究进展。我们得出结论，Fng1 参与了组蛋白乙酰化、去乙酰化和甲基化的相互作用。
