a Department of Forensic Sciences, Pathology, Gynecology and Obstetrics, and Pediatrics, Division of Toxicology , Universidade de Santiago de Compostela, Veterinary School , Avenida Carballo Calero, s/n, 27002 Lugo , Spain.
b Department of Otorhinolaryngology , Complexo Hospitalario Universitario Lucus Augusti , Calle Dr Ulises Romero, 1, 27003 Lugo , Spain.
Nutr Neurosci. 2018 Nov;21(9):624-631. doi: 10.1080/1028415X.2017.1327636. Epub 2017 May 19.
Although it is commonly recognized that dietary restrictions may improve the clinical course of Menière's disease, their effectiveness has not been definitely demonstrated. The aim of this study was to examine whether caffeine consumption could be involved in Menière's disease.
Cross-sectional, observational, case-control study, comparing caffeine consumption (intake of coffee, tea, kola-type beverages, energy drinks, and chocolate-containing beverages or foods) between patients with Menière's disease (group A) and patients affected by vertigo with other origins (group B) and/or control subjects (group C).
180 subjects (72 in group A, 72 in group B, and 36 in group C). Caffeine intake was categorized in four levels: very low (0-25 mg/day), low (26-100 mg/day), moderate (101-300 mg/day), and high (≥301 mg/day). Very low and low intake were considered light consumption, and moderate and high intake, heavy consumption.
Mean daily caffeine intake was 175.8 mg. Menière's disease patients showed a daily caffeine intake (222 mg) greater than those not affected by this disease (145 mg). Excluding in group B migraine patients, differences in caffeine intake are significant among the three groups (P = 0.021). There were significantly more heavy-consumers in group A than in other two groups jointed (P = 0.024; OR = 1.301, IC95% (1.015;1.668)). In group A, the age at onset of symptoms in caffeine consumers (49.7 years) was lower than in non-consumers (55.9 years).
It should be recommended to reduce caffeine intake in those population groups with higher risk of Menière's disease (e.g. subjects with family members suffering from this disease).
尽管人们普遍认为饮食限制可能改善梅尼埃病的临床病程，但尚未明确证实其有效性。本研究旨在探讨咖啡因的摄入是否与梅尼埃病有关。
这是一项横断面、观察性、病例对照研究，比较梅尼埃病患者（A 组）、其他原因引起眩晕的患者（B 组）和/或对照组（C 组）的咖啡因摄入情况（咖啡、茶、可乐型饮料、能量饮料和含巧克力饮料或食物的摄入）。
180 名受试者（A 组 72 例，B 组 72 例，C 组 36 例）。咖啡因摄入量分为 4 个水平：极低（0-25mg/天）、低（26-100mg/天）、中（101-300mg/天）和高（≥301mg/天）。极低和低摄入量被认为是轻度摄入，中高摄入量被认为是重度摄入。
平均每日咖啡因摄入量为 175.8mg。梅尼埃病患者的每日咖啡因摄入量（222mg）高于未患此病的患者（145mg）。排除 B 组偏头痛患者后，三组之间的咖啡因摄入量差异具有统计学意义（P=0.021）。与其他两组相比，A 组重度摄入者明显更多（P=0.024；OR=1.301，95%CI（1.015；1.668））。在 A 组中，咖啡因摄入者的症状发病年龄（49.7 岁）低于非摄入者（55.9 岁）。
应建议梅尼埃病高危人群（如患有此病的家庭成员）减少咖啡因的摄入。
