Ruksha Tatiana G, Komina Anna V, Palkina Nadezhda V
Department of Pathophysiology, Krasnoyarsk State Medical University, P. Zeleznyaka str. 1, 660022, Krasnoyarsk, Russian Federation.
Eur J Dermatol. 2017 Aug 1;27(4):343-352. doi: 10.1684/ejd.2017.3024.
MicroRNAs are essential regulators of various cellular processes such as cell growth, differentiation, apoptosis, and the immune response, acting as factors for translational repression and/or degradation of target messenger RNA. Currently, microRNAs are considered as promising biomarkers and therapeutic targets for different pathological conditions. Skin may serve as a convenient model for microRNA modulation studies due to the comparatively easy access to targets cells. Cutaneous diseases are characterized by multiple intercellular communication pathways, triggered by diverse stimuli and mediated by heterogenous regulators, including microRNAs. The goal of this article is to summarize the state of research in dermatology concerning the action of microRNAs as epigenetic modulators.
微小RNA是细胞生长、分化、凋亡和免疫反应等各种细胞过程的重要调节因子，可作为靶信使核糖核酸翻译抑制和/或降解的因子。目前，微小RNA被认为是不同病理状况下很有前景的生物标志物和治疗靶点。由于相对容易获取靶细胞，皮肤可能是微小RNA调节研究的便利模型。皮肤病的特征是存在多种细胞间通讯途径，这些途径由不同刺激触发，并由包括微小RNA在内的异质性调节因子介导。本文的目的是总结皮肤病学中有关微小RNA作为表观遗传调节因子作用的研究现状。
