微小 RNA 在炎症性和自身免疫性皮肤病中的重要作用——综述。
The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases-A Review.
机构信息
Department of Dermatology, Centre of Postgraduate Medical Education, 02-507 Warsaw, Poland.
Department of Dermatology, The National Institute of Medicine of the Ministry of the Interior and Administration, 02-507 Warsaw, Poland.
出版信息
Int J Mol Sci. 2023 May 23;24(11):9130. doi: 10.3390/ijms24119130.
The etiopathogenesis of autoimmune skin diseases is complex and still not fully understood. The role of epigenetic factors is emphasized in the development of such diseases. MicroRNAs (miRNAs), a group of non-coding RNAs (ncRNAs-non-coding RNAs), are one of the important post-transcriptional epigenetic factors. miRNAs have a significant role in the regulation of the immune response by participating in the process of the differentiation and activation of B and T lymphocytes, macrophages, and dendritic cells. Recent advances in research on epigenetic factors have provided new insights into the pathogenesis and potential diagnostic and therapeutic targets of many pathologies. Numerous studies revealed a change in the expression of some microRNAs in inflammatory skin disorders, and the regulation of miRNA expression is a promising therapeutic goal. This review presents the state of the art regarding changes in the expression and role of miRNAs in inflammatory and autoimmune skin diseases, including psoriasis, atopic dermatitis, vitiligo, lichen planus, hidradenitis suppurativa, and autoimmune blistering diseases.
自身免疫性皮肤病的发病机制复杂，目前尚不完全清楚。在这类疾病的发生发展中，表观遗传因素的作用受到重视。微小 RNA（miRNA）是一组非编码 RNA（ncRNA-非编码 RNA），是重要的转录后表观遗传因子之一。miRNA 通过参与 B 和 T 淋巴细胞、巨噬细胞和树突状细胞的分化和激活过程，在免疫反应的调节中发挥重要作用。近年来，对表观遗传因子的研究进展为许多病理的发病机制和潜在的诊断及治疗靶点提供了新的见解。大量研究表明，一些 miRNA 在炎症性皮肤疾病中的表达发生了改变，调控 miRNA 表达是一种很有前途的治疗目标。本文综述了 miRNA 在炎症性和自身免疫性皮肤病（包括银屑病、特应性皮炎、白癜风、扁平苔藓、化脓性汗腺炎和自身免疫性大疱病）中的表达和作用的最新研究进展。
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