Yanagita N, Koide J, Yokoi H
Department of Otolaryngology, Nagoya University School of Medicine, Japan.
Acta Otolaryngol Suppl. 1988;456:106-10. doi: 10.3109/00016488809125086.
Type 1 herpes simplex virus (HSV-1) was inoculated into the subarachnoid space through the cisterna magna of guinea pigs to study morphological changes of the inner ear and the ability of the cochlear aqueduct to protect the inner ear. Although most of the animals developed clinical manifestations of meningoencephalitis within a few days after inoculation, Preyer's reflex remained intact. Scanning electron microscopy revealed some significant changes in the cochlear aqueduct. Lymphocytes and macrophages were predominant, with narrowing of reticular tissue spaces caused by the swelling of the periotic duct tissue. The cribriform structure of the internal orifice of the cochlear aqueduct appeared to be completely obstructed, whereas it was normal in the presence of bacterial infection as previously reported (1). The morphological changes were confined to the cochlear aqueduct.
将1型单纯疱疹病毒（HSV-1）通过豚鼠的枕大池接种到蛛网膜下腔，以研究内耳的形态变化以及蜗水管对内耳的保护能力。尽管大多数动物在接种后几天内出现了脑膜脑炎的临床表现，但普赖尔反射仍保持完整。扫描电子显微镜显示蜗水管有一些显著变化。淋巴细胞和巨噬细胞占主导地位，耳周导管组织肿胀导致网状组织间隙变窄。蜗水管内口的筛状结构似乎完全阻塞，而如先前报道（1），在细菌感染时它是正常的。形态学变化仅限于蜗水管。
