1号染色体上的连锁基因座（FXIIIB、HF、PEPC）及其在巴西印第安人中的变异性。

Linked loci in chromosome 1 (FXIIIB, HF, PEPC) and their variability in Brazilian Indians.

作者信息

Kömpf J, Luckenbach Ch, Krczal D, Salzano F M, Callegari-Jacques S M

机构信息

Institut für Anthropologie und Humangenetik der Universität Tübingen, D-7400 Tübingen, Germany.

Departmento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, 91501 Porto Alegre, RS, Brazil.

出版信息

Am J Hum Biol. 1992;4(5):573-577. doi: 10.1002/ajhb.1310040503.

DOI:10.1002/ajhb.1310040503

PMID:28524593

Abstract

A total of 352 individuals living in seven localities of two Brazilian Indian groups (Macushi and Içana River Indians) were variously studied for coagulation factor XIIIB, human factor H, and a new polymorphism of peptidase C. No significant inter- or intra-tribal differences were found for the FXIIIB alleles, the frequencies varying around 95% for F13B3 and 5% for F13B1. Results for HF were heterogeneous, HF*A presenting a much higher frequency among the Macushi (32%) than among the Içana River Indians (9%). Intratribal differences were also found among both groups. Linkage disequilibrium exists between alleles of these two systems (0.03 ± 0.01). These are the first results for human factor H obtained among Amerindians. The data for PEPC were limited to the Içana River Indians. There is heterogeneity among the three localities sampled and evidence of moderate linkage disequilibrium between markers in this locus and in F13B (0.02 ± 0.01). © 1992 Wiley-Liss, Inc.

摘要

对居住在巴西两个印第安群体（马库希族和伊萨纳河印第安人）七个地区的352名个体进行了凝血因子XIIIB、人因子H和肽酶C新多态性的各种研究。未发现XIIIB等位基因在部落间或部落内存在显著差异，F13B3的频率约为95%，F13B1的频率约为5%。因子H的结果存在异质性，HF*A在马库希族中的频率（32%）远高于伊萨纳河印第安人（9%）。在这两个群体中也发现了部落内差异。这两个系统的等位基因之间存在连锁不平衡（0.03±0.01）。这些是在美洲印第安人中获得的关于人因子H的首批结果。肽酶C的数据仅限于伊萨纳河印第安人。在抽样的三个地区存在异质性，并且该基因座与F13B中的标记之间存在中度连锁不平衡的证据（0.02±0.01）。©1992威利 - 利斯公司。