Aksnes L, Rødland O, Aarskog D
Department of Pediatrics, University of Bergen, Norway.
Bone Miner. 1988 Mar;3(4):351-7.
Serum levels of vitamin D3, 25(OH)D3, and vitamin D binding protein (DBP) were measured in a group of elderly subjects (71-96 years) and a group of young adults (22-40 years). The mean serum levels of vitamin D3, 25(OH)D3 and DBP were significantly lower in the elderly subjects compared to the young adults. The mean molar ratio of 25(OH)D3 to vitamin D3 was significantly higher in the elderly compared to the young adults. A parabolic relationship was found between the serum levels of 25(OH)D3 and vitamin D3 in both groups. This relationship gives a higher ratio of the serum levels of 25(OH)D3 to vitamin D3 in the lower part of the vitamin D3 range. Our data do not indicate impaired hepatic 25-hydroxylation of vitamin D3 in the elderly.
在一组老年受试者（71 - 96岁）和一组年轻成年人（22 - 40岁）中测量了血清维生素D3、25(OH)D3和维生素D结合蛋白（DBP）的水平。与年轻成年人相比，老年受试者血清维生素D3、25(OH)D3和DBP的平均水平显著降低。与年轻成年人相比，老年人中25(OH)D3与维生素D3的平均摩尔比显著更高。在两组中均发现25(OH)D3和维生素D3的血清水平之间存在抛物线关系。这种关系在维生素D3范围的较低部分给出了更高的25(OH)D3与维生素D3血清水平之比。我们的数据并未表明老年人中维生素D3的肝脏25 - 羟化受损。
