McGrath John, Scragg Robert, Chant David, Eyles Darryl, Burne Thomas, Obradovic Darja
Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Australia.
Neuroepidemiology. 2007;29(1-2):49-54. doi: 10.1159/000108918. Epub 2007 Sep 24.
Animal studies and in vitro experiments indicate that vitamin D is involved in a diverse range of neurobiological functions. We had the opportunity to examine the relationship between serum 25-hydroxyvitamin D(3) [25(OH)D] levels and performance on various cognitive tasks, based on a large, representative community sample.
Three age groups were available from the population-based NHANES III survey: adolescent group (n = 1,676, age range 12-17 years), adult group (n = 4,747, 20-60 years), elderly group (n = 4,809, 60-90 years). The associations between eight psychometric measures and serum 25(OH)D were assessed.
In the adolescent and adult groups, none of the psychometric measures were associated with 25(OH)D levels. In the elderly group there was a significant difference between 25(OH)D quintiles performance on a learning and memory task; however, those with the highest quintile of 25(OH)D were most impaired on the task, contrary to the hypotheses.
Lower 25(OH)D levels were not associated with impaired performance on various psychometric measures. While it remains to be seen if chronic exposure to low 25(OH)D levels alters brain function in the long term, this cross-sectional study suggests that 25(OH)D levels do not influence neurocognitive performance.
动物研究和体外实验表明，维生素D参与多种神经生物学功能。基于一个大型、具有代表性的社区样本，我们有机会研究血清25-羟基维生素D3[25(OH)D]水平与各种认知任务表现之间的关系。
基于人群的美国国家健康与营养检查调查（NHANES III）中有三个年龄组：青少年组（n = 1676，年龄范围12 - 17岁）、成人组（n = 4747，20 - 60岁）、老年组（n = 4809，60 - 90岁）。评估了八项心理测量指标与血清25(OH)D之间的关联。
在青少年组和成人组中，没有一项心理测量指标与25(OH)D水平相关。在老年组中，25(OH)D五分位数在学习和记忆任务上的表现存在显著差异；然而，与假设相反，25(OH)D五分位数最高的人群在该任务上受损最严重。
较低的25(OH)D水平与各种心理测量指标的表现受损无关。虽然长期慢性暴露于低25(OH)D水平是否会改变脑功能还有待观察，但这项横断面研究表明，25(OH)D水平不会影响神经认知表现。
