Lazzerini Ospri Lorenzo, Prusky Glen, Hattar Samer
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; email:
Department of Physiology and Biophysics, Cornell University, Ithaca, New York 10065.
Annu Rev Neurosci. 2017 Jul 25;40:539-556. doi: 10.1146/annurev-neuro-072116-031324. Epub 2017 May 17.
The discovery of a third type of photoreceptors in the mammalian retina, intrinsically photosensitive retinal ganglion cells (ipRGCs), has had a revolutionary impact on chronobiology. We can now properly account for numerous non-vision-related functions of light, including its effect on the circadian system. Here, we give an overview of ipRGCs and their function as it relates specifically to mood and biological rhythms. Although circadian disruptions have been traditionally hypothesized to be the mediators of light's effects on mood, here we present an alternative model that dispenses with assumptions of causality between the two phenomena and explains mood regulation by light via another ipRGC-dependent mechanism.
哺乳动物视网膜中第三种光感受器——内在光敏视网膜神经节细胞（ipRGCs）的发现，对生物钟学产生了革命性的影响。我们现在能够恰当地解释光的许多与视觉无关的功能，包括其对昼夜节律系统的影响。在此，我们概述了ipRGCs及其与情绪和生物节律特别相关的功能。尽管传统上认为昼夜节律紊乱是光影响情绪的介质，但在此我们提出了另一种模型，该模型摒弃了这两种现象之间因果关系的假设，并通过另一种依赖ipRGCs的机制来解释光对情绪的调节。
