Garces Estefany, Slota Katarzyna, Stewart Michael W, Guzman Maria P, Werninck Natalia M, Castillo Pablo R
Division of Pulmonary, Allergy and Sleep Medicine, Mayo Clinic College of Medicine and Science, Jacksonville, FL, USA.
Northwest Community Healthcare, Schaumburg, IL, USA.
Clin Ophthalmol. 2025 Mar 13;19:899-905. doi: 10.2147/OPTH.S487389. eCollection 2025.
Age-related macular degeneration (AMD) is the leading cause of blindness in developed nations. Within the retina, a subset of cells, called , are implicated in circadian rhythms, prompting a search for a potential connection between circadian behavior and AMD. Our objective was to compare the chronotype (ie, preference for morning or evening activity) of individuals with AMD to that of those without ocular conditions.
The Horne-Östberg Morningness-Eveningness questionnaire was administered to previously screened patients with wet AMD who received bilateral anti-vascular endothelial growth factor eye injections (study participants) as well as those without eye pathology (controls). Thirty-one study participants and 19 controls completed the survey and were included in the analysis. We used Wilcoxon rank sum test and Fisher exact test for continuous and categorical variables respectively.
Study participants had a higher median age compared to controls (83 vs 75, <0.001). No significant difference in body mass index was observed between respondents. While the disparity in survey responses between study participants and controls was generally not statistically significant, more study participants struggled with attending exercises between 7:00 and 8:00 in the morning compared to controls (45% vs 21%, =0.02). Additionally, fewer study participants expressed the need to sleep before 10:15 pm compared to controls (55% vs 63%, =0.04). Study participants tended to have a delayed sleep-wake cycle.
In this pilot study, study participants encountered greater challenges with morning exercise compared to controls. Nonetheless, there was no significant difference in chronotype between study participants and controls. The study could serve as a foundation for more extensive research exploring the interplay between vision loss and circadian rhythms.
年龄相关性黄斑变性（AMD）是发达国家失明的主要原因。在视网膜内，一种被称为 的细胞亚群与昼夜节律有关，这促使人们寻找昼夜行为与AMD之间的潜在联系。我们的目的是比较患有AMD的个体与没有眼部疾病的个体的昼夜类型（即对早晨或晚上活动的偏好）。
对先前筛选过的接受双侧抗血管内皮生长因子眼部注射的湿性AMD患者（研究参与者）以及没有眼部病变的患者（对照组）进行了霍恩-奥斯特伯格晨型-夜型问卷调查。31名研究参与者和19名对照完成了调查并纳入分析。我们分别对连续变量和分类变量使用了Wilcoxon秩和检验和Fisher精确检验。
与对照组相比，研究参与者的年龄中位数更高（83岁对75岁，<0.001）。在受访者之间未观察到体重指数的显著差异。虽然研究参与者和对照组在调查回答上的差异通常无统计学意义，但与对照组相比，更多的研究参与者在早上7:00至8:00之间参加锻炼时存在困难（45%对21%，=0.02）。此外，与对照组相比，表达需要在晚上10:15之前睡觉的研究参与者更少（55%对63%，=0.04）。研究参与者往往有延迟的睡眠-觉醒周期。
在这项初步研究中，与对照组相比，研究参与者在晨练方面面临更大的挑战。尽管如此，研究参与者和对照组在昼夜类型上没有显著差异。该研究可为更广泛地探索视力丧失与昼夜节律之间的相互作用的研究奠定基础。
