核纤层相关结构域：与染色体结构、异染色质及基因抑制的联系
Lamina-Associated Domains: Links with Chromosome Architecture, Heterochromatin, and Gene Repression.
作者信息
van Steensel Bas, Belmont Andrew S
机构信息
Division of Gene Regulation, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands; Department of Cell Biology, Erasmus University Medical Center, 3015 CE Rotterdam, the Netherlands.
Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
出版信息
Cell. 2017 May 18;169(5):780-791. doi: 10.1016/j.cell.2017.04.022.
Abstract
In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize chromosomes inside the nucleus and have been associated with gene repression. Here, we discuss the properties of LADs, the molecular mechanisms that determine their association with the nuclear lamina, their dynamic links with other nuclear compartments, and their proposed roles in gene regulation.
摘要
在多细胞动物的细胞核中，数百个大的染色质结构域与核纤层紧密接触。这种与核纤层相关的结构域（LADs）被认为有助于在细胞核内组织染色体，并与基因抑制有关。在这里，我们讨论了LADs的特性、决定它们与核纤层关联的分子机制、它们与其他核区室的动态联系以及它们在基因调控中所提出的作用。
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