核纤层相关结构域：与染色体结构、异染色质及基因抑制的联系
Lamina-Associated Domains: Links with Chromosome Architecture, Heterochromatin, and Gene Repression.
作者信息
van Steensel Bas, Belmont Andrew S
机构信息
Division of Gene Regulation, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands; Department of Cell Biology, Erasmus University Medical Center, 3015 CE Rotterdam, the Netherlands.
Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
出版信息
Cell. 2017 May 18;169(5):780-791. doi: 10.1016/j.cell.2017.04.022.
Abstract
In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize chromosomes inside the nucleus and have been associated with gene repression. Here, we discuss the properties of LADs, the molecular mechanisms that determine their association with the nuclear lamina, their dynamic links with other nuclear compartments, and their proposed roles in gene regulation.
摘要
在多细胞动物的细胞核中，数百个大的染色质结构域与核纤层紧密接触。这种与核纤层相关的结构域（LADs）被认为有助于在细胞核内组织染色体，并与基因抑制有关。在这里，我们讨论了LADs的特性、决定它们与核纤层关联的分子机制、它们与其他核区室的动态联系以及它们在基因调控中所提出的作用。
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本文引用的文献
1
3D structures of individual mammalian genomes studied by single-cell Hi-C.通过单细胞Hi-C技术研究的单个哺乳动物基因组的三维结构。
Nature. 2017 Apr 6;544(7648):59-64. doi: 10.1038/nature21429. Epub 2017 Mar 13.
2
Nucleoporin-mediated regulation of cell identity genes.核孔蛋白介导的细胞身份基因调控。
Genes Dev. 2016 Oct 15;30(20):2253-2258. doi: 10.1101/gad.287417.116. Epub 2016 Nov 2.
3
A-type Lamins Form Distinct Filamentous Networks with Differential Nuclear Pore Complex Associations.A型核纤层蛋白形成具有不同核孔复合体关联的独特丝状网络。
Curr Biol. 2016 Oct 10;26(19):2651-2658. doi: 10.1016/j.cub.2016.07.049. Epub 2016 Sep 15.
4
Physiological and Pathological Aging Affects Chromatin Dynamics, Structure and Function at the Nuclear Edge.生理衰老和病理衰老影响核边缘的染色质动力学、结构和功能。
Front Genet. 2016 Aug 23;7:153. doi: 10.3389/fgene.2016.00153. eCollection 2016.
5
Transcription upregulation via force-induced direct stretching of chromatin.通过力诱导的染色质直接拉伸实现转录上调。
Nat Mater. 2016 Dec;15(12):1287-1296. doi: 10.1038/nmat4729. Epub 2016 Aug 22.
6
Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing.Xist 将 X 染色体募集到核纤层，从而实现全染色体沉默。
Science. 2016 Oct 28;354(6311):468-472. doi: 10.1126/science.aae0047. Epub 2016 Aug 4.
7
Transcription factors dynamically control the spatial organization of the yeast genome.转录因子动态控制酵母基因组的空间组织。
Nucleus. 2016 Jul 3;7(4):369-74. doi: 10.1080/19491034.2016.1212797. Epub 2016 Jul 21.
8
Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment.机械调控转录控制多梳介导的基因沉默在谱系承诺期间。
Nat Cell Biol. 2016 Aug;18(8):864-75. doi: 10.1038/ncb3387. Epub 2016 Jul 11.
9
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Mol Cell. 2016 Jun 16;62(6):834-847. doi: 10.1016/j.molcel.2016.04.035. Epub 2016 Jun 2.
10
Nongenetic functions of the genome.基因组的非遗传功能。
Science. 2016 May 6;352(6286):aad6933. doi: 10.1126/science.aad6933.
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