Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada, K7L 3N6.
Trends Microbiol. 2017 Oct;25(10):820-832. doi: 10.1016/j.tim.2017.04.010. Epub 2017 May 17.
Environmental influences on antibiotic activity and resistance can wreak havoc with in vivo antibiotic efficacy and, ultimately, antimicrobial chemotherapy. In nature, bacteria encounter a variety of metal ions, particularly copper (Cu) and zinc (Zn), as contaminants in soil and water, as feed additives in agriculture, as clinically-used antimicrobials, and as components of human antibacterial responses. Importantly, there is a growing body of evidence for Cu/Zn driving antibiotic resistance development in metal-exposed bacteria, owing to metal selection of genetic elements harbouring both metal and antibiotic resistance genes, and metal recruitment of antibiotic resistance mechanisms. Many classes of antibiotics also form complexes with metal cations, including Cu and Zn, and this can hinder (or enhance) antibiotic activity. This review highlights the ways in which Cu/Zn influence antibiotic resistance development and antibiotic activity, and in so doing impact in vivo antibiotic efficacy.
环境对抗生素活性和耐药性的影响可能会严重破坏体内抗生素的疗效，并最终影响抗菌化疗。在自然界中，细菌在土壤和水中遇到各种金属离子，特别是铜 (Cu) 和锌 (Zn)，作为污染物，作为农业中的饲料添加剂，作为临床使用的抗菌药物，以及作为人类抗菌反应的组成部分。重要的是，越来越多的证据表明，Cu/Zn 推动了金属暴露细菌中抗生素耐药性的发展，这是由于含有金属和抗生素耐药基因的遗传元件的金属选择，以及抗生素耐药机制的金属招募。许多类抗生素也与金属阳离子（包括 Cu 和 Zn）形成复合物，这会阻碍（或增强）抗生素的活性。这篇综述强调了 Cu/Zn 影响抗生素耐药性发展和抗生素活性的方式，并因此影响体内抗生素的疗效。
