Ding Binbin, Zhong Qing
Center for Autophagy Research, Department of Internal Medicine, Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Center for Autophagy Research, Department of Internal Medicine, Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
J Biol Chem. 2017 May 19;292(20):8531-8532. doi: 10.1074/jbc.H116.762948.
Cells respond to deprivation of certain nutrients such as glucose or nitrogen by inducing autophagy, reclaiming pieces of proteins for use in critical functions. A recent study shows that, in yeast, zinc depletion acts in a similar fashion. Depletion of this essential nutrient induces non-selective autophagy by inhibiting TORC1, leading to release and recycling of zinc from degraded proteins.
细胞通过诱导自噬来应对某些营养物质（如葡萄糖或氮）的缺乏，回收蛋白质片段以用于关键功能。最近的一项研究表明，在酵母中，锌缺乏也以类似的方式起作用。这种必需营养素的缺乏通过抑制TORC1诱导非选择性自噬，导致锌从降解的蛋白质中释放并循环利用。
