Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, MA, 02115, USA; Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, 02111, USA.
Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, 02111, USA.
Mutat Res Rev Mutat Res. 2017 Apr-Jun;772:3-12. doi: 10.1016/j.mrrev.2016.07.002. Epub 2016 Jul 5.
Human papillomaviruses are small DNA viruses with a tropism for squamous epithelia. A unique aspect of human papillomavirus molecular biology involves dependence on the differentiation status of the host epithelial cell to complete the viral lifecycle. A small group of these viruses are the etiologic agents of several types of human cancers, including oral and anogenital tract carcinomas. This review focuses on the basic molecular biology of human papillomaviruses.
人乳头瘤病毒是一种小型 DNA 病毒，对鳞状上皮具有嗜性。人乳头瘤病毒分子生物学的一个独特方面涉及到依赖宿主上皮细胞的分化状态来完成病毒生命周期。其中一小部分病毒是几种人类癌症的病原体，包括口腔和肛门生殖道癌。本文重点介绍人乳头瘤病毒的基本分子生物学。
