人乳头瘤病毒分子生物学。
Human papillomavirus molecular biology.
机构信息
Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, MA, 02115, USA; Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, 02111, USA.
Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, 02111, USA.
出版信息
Mutat Res Rev Mutat Res. 2017 Apr-Jun;772:3-12. doi: 10.1016/j.mrrev.2016.07.002. Epub 2016 Jul 5.
Abstract
Human papillomaviruses are small DNA viruses with a tropism for squamous epithelia. A unique aspect of human papillomavirus molecular biology involves dependence on the differentiation status of the host epithelial cell to complete the viral lifecycle. A small group of these viruses are the etiologic agents of several types of human cancers, including oral and anogenital tract carcinomas. This review focuses on the basic molecular biology of human papillomaviruses.
摘要
人乳头瘤病毒是一种小型 DNA 病毒，对鳞状上皮具有嗜性。人乳头瘤病毒分子生物学的一个独特方面涉及到依赖宿主上皮细胞的分化状态来完成病毒生命周期。其中一小部分病毒是几种人类癌症的病原体，包括口腔和肛门生殖道癌。本文重点介绍人乳头瘤病毒的基本分子生物学。
相似文献
1
Human papillomavirus molecular biology.人乳头瘤病毒分子生物学。
Mutat Res Rev Mutat Res. 2017 Apr-Jun;772:3-12. doi: 10.1016/j.mrrev.2016.07.002. Epub 2016 Jul 5.
2
Biology and pathological associations of the human papillomaviruses: a review.人乳头瘤病毒的生物学及病理学关联：综述
Malays J Pathol. 1998 Jun;20(1):1-10.
3
4
Should the treatment paradigms for oral and oropharyngeal cancers be changed now: the role of human papilloma virus?口腔和口咽癌的治疗模式现在是否应该改变：人乳头瘤病毒的作用？
ANZ J Surg. 2011 Sep;81(9):581-3. doi: 10.1111/j.1445-2197.2011.05829.x.
5
Head and neck squamous cell carcinoma: role of the human papillomavirus in tumour progression.头颈部鳞状细胞癌：人乳头瘤病毒在肿瘤进展中的作用
New Microbiol. 2006 Jan;29(1):25-33.
6
Expression of p16(INK4A), p53, and Rb proteins are independent from the presence of human papillomavirus genes in oral squamous cell carcinoma.p16（INK4A）、p53和Rb蛋白的表达与口腔鳞状细胞癌中人类乳头瘤病毒基因的存在无关。
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Sep;102(3):344-52. doi: 10.1016/j.tripleo.2005.10.069. Epub 2006 Mar 20.
7
Human papillomavirus infection in oral squamous cell carcinomas from Chilean patients.智利患者口腔鳞状细胞癌中的人乳头瘤病毒感染
Exp Mol Pathol. 2015 Aug;99(1):95-9. doi: 10.1016/j.yexmp.2015.06.001. Epub 2015 Jun 6.
8
The natural history of human papillomavirus infections of the mucosal epithelia.黏膜上皮人乳头瘤病毒感染的自然史。
APMIS. 2010 Jun;118(6-7):422-49. doi: 10.1111/j.1600-0463.2010.02625.x.
9
Propagation of infectious human papillomavirus type 16 by using an adenovirus and Cre/LoxP mechanism.利用腺病毒和Cre/LoxP机制传播人乳头瘤病毒16型。
Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2094-9. doi: 10.1073/pnas.0308615100. Epub 2004 Feb 9.
10
A postulated role for human papillomavirus (HPV) in the transformation and proliferation of oral squamous cell carcinoma (OSCC).人乳头瘤病毒（HPV）在口腔鳞状细胞癌（OSCC）的转化和增殖中假定的作用。
Med Hypotheses. 2008;70(5):1041-3. doi: 10.1016/j.mehy.2007.07.043. Epub 2007 Oct 29.
引用本文的文献
1
Harnessing the Power of Microbiota: How Do Key Species Aid in Clearing High-Risk Human Papilloma Virus Infection and Promoting the Regression of Cervical Dysplasia?利用微生物群的力量：关键物种如何帮助清除高危型人乳头瘤病毒感染并促进宫颈发育异常的消退？
Biology (Basel). 2025 Aug 19;14(8):1081. doi: 10.3390/biology14081081.
2
Emerging nanotherapeutics for HPV-associated cancers: current advances, challenges, and future directions.用于人乳头瘤病毒相关癌症的新型纳米疗法：当前进展、挑战及未来方向
Discov Oncol. 2025 Aug 29;16(1):1653. doi: 10.1007/s12672-025-02439-w.
3
Role of NTRK Fusion Genes in the Tumor Immune Microenvironment of HPV (+/-) Cervical Cancer.NTRK融合基因在人乳头瘤病毒（±）宫颈癌肿瘤免疫微环境中的作用
J Med Virol. 2025 Aug;97(8):e70564. doi: 10.1002/jmv.70564.
4
Oncoviruses in the Oral Cavity: Recent Advances in Understanding Viral Infections and Tumorigenesis.口腔中的肿瘤病毒：病毒感染与肿瘤发生认识的最新进展
Int J Mol Sci. 2025 Jul 13;26(14):6721. doi: 10.3390/ijms26146721.
5
The necessity and challenges of human papillomavirus testing for men.男性人乳头瘤病毒检测的必要性与挑战
Front Cell Infect Microbiol. 2025 Jun 30;15:1563499. doi: 10.3389/fcimb.2025.1563499. eCollection 2025.
6
Analysis of Human Papillomavirus-HPV-18 and HPV-45 Type-specific variants in a contemporary cohort of individuals with cervical disease in Ghana.加纳当代宫颈疾病患者队列中人类乳头瘤病毒18型（HPV-18）和45型（HPV-45）特异性变体的分析
Ghana Med J. 2024 Dec;58(4):311-321. doi: 10.4314/gmj.v58i4.9.
7
Viral infection and thyroid disorders: a narrative review.病毒感染与甲状腺疾病：一篇综述
Front Microbiol. 2025 Jun 13;16:1625179. doi: 10.3389/fmicb.2025.1625179. eCollection 2025.
8
Women suffering from overactive bladder syndrome exhibit a higher urethral viral abundance compared to healthy controls: a pilot study.与健康对照相比，患有膀胱过度活动症的女性尿道病毒丰度更高：一项试点研究。
Sci Rep. 2025 Jun 3;15(1):19484. doi: 10.1038/s41598-025-98780-9.
9
Hypoxic HPV-Positive Cancer Cells Are Particularly Sensitive to the Pro-Senescent Effects of B-MYB Repression Due to the Lack of Compensatory A-MYB Induction.由于缺乏代偿性A-MYB诱导，低氧人乳头瘤病毒阳性癌细胞对B-MYB抑制的促衰老效应尤为敏感。
J Med Virol. 2025 Jun;97(6):e70422. doi: 10.1002/jmv.70422.
10
Human papillomavirus E1 proteins inhibit RIG-I/MDA5-MAVS, TLR3-TRIF, cGAS-STING, and JAK-STAT signaling pathways to evade innate antiviral immunity.人乳头瘤病毒E1蛋白抑制RIG-I/MDA5-MAVS、TLR3-TRIF、cGAS-STING和JAK-STAT信号通路以逃避先天性抗病毒免疫。
Front Immunol. 2025 Apr 22;16:1549766. doi: 10.3389/fimmu.2025.1549766. eCollection 2025.
本文引用的文献
1
Prevention of cervical cancer: journey to develop the first human papillomavirus virus-like particle vaccine and the next generation vaccine.宫颈癌的预防：研发首款人乳头瘤病毒样颗粒疫苗及下一代疫苗的历程
Curr Opin Chem Biol. 2016 Jun;32:34-47. doi: 10.1016/j.cbpa.2016.03.001. Epub 2016 Mar 18.
2
The budget impact of cervical cancer screening using HPV primary screening.采用人乳头瘤病毒（HPV）初筛进行宫颈癌筛查的预算影响
Am J Manag Care. 2016 Mar 1;22(3):e95-105.
3
Current state in the development of candidate therapeutic HPV vaccines.候选治疗性人乳头瘤病毒疫苗的研发现状
Expert Rev Vaccines. 2016 Aug;15(8):989-1007. doi: 10.1586/14760584.2016.1157477. Epub 2016 Mar 7.
4
Preventing Cervical Cancer in the United States: Barriers and Resolutions for HPV Vaccination.美国宫颈癌的预防：人乳头瘤病毒疫苗接种的障碍与解决办法
Front Oncol. 2016 Feb 1;6:19. doi: 10.3389/fonc.2016.00019. eCollection 2016.
5
Cleavage of the HPV16 Minor Capsid Protein L2 during Virion Morphogenesis Ablates the Requirement for Cellular Furin during De Novo Infection.在病毒体形态发生过程中HPV16次要衣壳蛋白L2的切割消除了初次感染期间对细胞弗林蛋白酶的需求。
Viruses. 2015 Nov 11;7(11):5813-30. doi: 10.3390/v7112910.
6
A Novel PDZ Domain Interaction Mediates the Binding between Human Papillomavirus 16 L2 and Sorting Nexin 27 and Modulates Virion Trafficking.一种新型的PDZ结构域相互作用介导人乳头瘤病毒16型L2与分选连接蛋白27之间的结合并调节病毒粒子运输。
J Virol. 2015 Oct;89(20):10145-55. doi: 10.1128/JVI.01499-15. Epub 2015 Jul 22.
7
Evaluation of the Long-Term Anti-Human Papillomavirus 6 (HPV6), 11, 16, and 18 Immune Responses Generated by the Quadrivalent HPV Vaccine.四价人乳头瘤病毒疫苗产生的长期抗人乳头瘤病毒6型（HPV6）、11型、16型和18型免疫反应的评估
Clin Vaccine Immunol. 2015 Aug;22(8):943-8. doi: 10.1128/CVI.00133-15. Epub 2015 Jun 17.
8
Human Papillomavirus Infectious Entry and Trafficking Is a Rapid Process.人乳头瘤病毒感染性进入和转运是一个快速过程。
J Virol. 2015 Sep;89(17):8727-32. doi: 10.1128/JVI.00722-15. Epub 2015 Jun 10.
9
Interaction of human tumor viruses with host cell surface receptors and cell entry.人类肿瘤病毒与宿主细胞表面受体的相互作用及细胞进入
Viruses. 2015 May 22;7(5):2592-617. doi: 10.3390/v7052592.
10
Point-Counterpoint: Cervical Cancer Screening Should Be Done by Primary Human Papillomavirus Testing with Genotyping and Reflex Cytology for Women over the Age of 25 Years.针锋相对：25岁以上女性的宫颈癌筛查应通过人乳头瘤病毒（HPV）初筛、基因分型及必要时的细胞学检查来进行。
J Clin Microbiol. 2015 Sep;53(9):2798-804. doi: 10.1128/JCM.01087-15. Epub 2015 May 6.
Zotero 插件