Gao Duyang, Yuan Zhen
Bioimaging Core, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Int J Biol Sci. 2017 Feb 25;13(4):401-412. doi: 10.7150/ijbs.18750. eCollection 2017.
Multimodal nanoprobes have attracted intensive attentions since they can integrate various imaging modalities to obtain complementary merits of single modality. Meanwhile, recent interest in laser-induced photoacoustic imaging is rapidly growing due to its unique advantages in visualizing tissue structure and function with high spatial resolution and satisfactory imaging depth. In this review, we summarize multimodal nanoprobes involving photoacoustic imaging. In particular, we focus on the method to construct multimodal nanoprobes. We have divided the synthetic methods into two types. First, we call it "one for all" concept, which involves intrinsic properties of the element in a single particle. Second, "all in one" concept, which means integrating different functional blocks in one particle. Then, we simply introduce the applications of the multifunctional nanoprobes for in vivo imaging and imaging-guided tumor therapy. At last, we discuss the advantages and disadvantages of the present methods to construct the multimodal nanoprobes and share our viewpoints in this area.
多模态纳米探针因其能够整合多种成像方式以获得单模态的互补优势而备受关注。与此同时，由于激光诱导光声成像在以高空间分辨率和令人满意的成像深度可视化组织结构和功能方面具有独特优势，近期对其的兴趣正在迅速增长。在本综述中，我们总结了涉及光声成像的多模态纳米探针。特别地，我们专注于构建多模态纳米探针的方法。我们将合成方法分为两类。第一类，我们称之为“一专多能”概念，它涉及单个粒子中元素的固有特性。第二类，“集于一体”概念，即意味着在一个粒子中整合不同的功能模块。然后，我们简要介绍多功能纳米探针在体内成像和成像引导肿瘤治疗中的应用。最后，我们讨论了构建多模态纳米探针的现有方法的优缺点，并分享我们在该领域的观点。
