State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China.
Anal Chem. 2022 Apr 5;94(13):5317-5324. doi: 10.1021/acs.analchem.1c05195. Epub 2022 Mar 23.
It is challenging to fabricate multimodal imaging nanoprobes with high penetration depth and long blood circulation. Herein, we present multifunctional fluorinated nanoprobes (CFPP NPs) containing formed copper chalcogenide nanoparticles for F magnetic resonance imaging (MRI) and photoacoustic imaging (PAI). The formed hydrophilic copper chalcogenide nanoassemblies demonstrated easy excretion stemming from facile disassembly, enhanced photothermal ability, and novel localized surface plasmon resonance (LSPR) absorption (centered at 1064 nm) in the "biological transparent" region. Both F MRI and PAI render these CFPP NPs suitable for multimodal imaging with high penetration depth and low background. Moreover, the chemo-photothermal synergistic therapy results suggest great potential in multimodal nanoprobes for imaging-guided tumor therapy applications.
制备具有高穿透深度和长血液循环时间的多模态成像纳米探针具有挑战性。在此，我们提出了多功能氟化纳米探针（CFPP NPs），其中包含形成的铜硫属化物纳米颗粒，用于 F 磁共振成像（MRI）和光声成像（PAI）。形成的亲水性铜硫属化物纳米组装体表现出易于排泄的特点，这源于其易于分解、增强的光热能力和新型局域表面等离子体共振（LSPR）吸收（位于 1064nm）在“生物透明”区域。F MRI 和 PAI 使这些 CFPP NPs 适合具有高穿透深度和低背景的多模态成像。此外，化学-光热协同治疗结果表明，在用于成像引导肿瘤治疗的多模态纳米探针中具有很大的应用潜力。
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