Ingerslev Kasper, Hogdall Estrid, Schnack Tine Henrichsen, Skovrider-Ruminski Wojciech, Hogdall Claus, Blaakaer Jan
Department of Gynaecology and Obstetrics, Odense University Hospital, Denmark, Soendre Blvd. 29, 5000 Odense C, Denmark.
Department of Pathology, Herlev and Gentofte Hospital, Denmark, Herlev Ringvej 75, 2730 Herlev, Denmark.
Infect Agent Cancer. 2017 May 18;12:25. doi: 10.1186/s13027-017-0134-9. eCollection 2017.
The etiological cause of ovarian cancer is poorly understood. It has been theorized that bacterial or viral infection as well as pelvic inflammatory disease could play a role in ovarian carcinogenesis.
To review the literature on studies examining the association between ovarian cancer and bacterial or viral infection or pelvic inflammatory disease.
Database search through MEDLINE, applying the medical subject headings: "Ovarian neoplasms", AND "Chlamydia infections", "", "", "Papillomaviridae", or "pelvic inflammatory disease". Corresponding searches were performed in EMBASE, and Web of Science. The literature search identified 935 articles of which 40 were eligible for inclusion in this review.
Seven studies examined the association between bacterial infection and ovarian cancer. A single study found a significant association between chlamydial infection and ovarian cancer, while another study identified in a large proportion of ovarian cancer cases. The remaining studies found no association. Human papillomavirus detection rates varied from 0 to 67% and were generally higher in the Asian studies than in studies from Western countries. Cytomegalovirus was the only other virus to be detected and was found in 50% of cases in a case-control study. The association between ovarian cancer and pelvic inflammatory disease was examined in seven epidemiological studies, two of which, reported a statistically significant association.
Data indicate a potential association between pelvic inflammatory disease and ovarian cancer. An association between ovarian cancer and high-risk human papillomavirus genotypes may exist in Asia, whereas an association in Western countries seems unlikely due to the low reported prevalence. Potential carcinogenic bacteria were found, but results were inconsistent, and further research is warranted.
卵巢癌的病因尚不清楚。理论上认为，细菌或病毒感染以及盆腔炎可能在卵巢癌发生过程中起作用。
综述关于研究卵巢癌与细菌或病毒感染或盆腔炎之间关联的文献。
通过MEDLINE进行数据库检索，应用医学主题词：“卵巢肿瘤”以及“衣原体感染”、“”、“”、“乳头瘤病毒科”或“盆腔炎”。在EMBASE和科学网进行了相应检索。文献检索共识别出935篇文章，其中40篇符合纳入本综述的条件。
七项研究探讨了细菌感染与卵巢癌之间的关联。一项研究发现衣原体感染与卵巢癌之间存在显著关联，而另一项研究在很大比例的卵巢癌病例中发现了 。其余研究未发现关联。人乳头瘤病毒检测率在0%至67%之间，亚洲研究中的检测率通常高于西方国家的研究。巨细胞病毒是唯一检测到的其他病毒，在一项病例对照研究中，50%的病例中检测到该病毒。七项流行病学研究探讨了卵巢癌与盆腔炎之间的关联，其中两项报告了具有统计学意义的关联。
数据表明盆腔炎与卵巢癌之间可能存在关联。在亚洲，卵巢癌与高危人乳头瘤病毒基因型之间可能存在关联，而在西方国家，由于报告的患病率较低，似乎不太可能存在关联。发现了潜在的致癌细菌，但结果不一致，有必要进行进一步研究。
