Li Li, Ji Guoping, Liang Li-Jung, Lin Chunqing, Hsieh Julie, Lan Chiao-Wen, Xiao Yongkang
Semel Institute for Neuroscience and Human Behavior, Center for Community Health, University of California at Los Angeles.
Anhui Provincial Center for Women and Child Health.
Health Psychol. 2017 Sep;36(9):863-871. doi: 10.1037/hea0000503. Epub 2017 May 22.
HIV has a profound impact on infected individuals and their families. This study evaluated the efficacy of an intervention aimed at improving the mental health of people living with HIV (PLH) and their family members.
A randomized controlled trial of 475 PLH and 522 family members was conducted in Anhui, China. The intervention comprised activities at individual, family, and community levels. The study outcomes, which included depressive symptoms and coping with illness for the PLH and depressive symptoms and caregiver burden for the family members, were assessed at baseline and at 6-, 12-, 18-, and 24-month follow-up. We used a mixed-effects regression model with village- and participant-level random effects to assess the intervention effect on the improvement of outcome measures.
Relative to the control condition, the PLH and family members of the intervention group reported a significant reduction in depressive symptoms. The largest difference in depressive symptoms was observed at 6 months for the PLH and at 12 months for family members. Decreases in perceived caregiver burden over time were observed for family members in both conditions; however, the group difference did not reach statistical significance. Significant intervention effect on the coping with illness was reported by the PLH.
The study highlights the importance of empowering families affected by HIV to confront the challenges together rather than individually. It may be optimal for future programs to include both PLH and their family members to maximize intervention effects through strengthening interactions and support within a family. (PsycINFO Database Record
艾滋病病毒对感染者及其家庭有深远影响。本研究评估了一项旨在改善艾滋病病毒感染者（PLH）及其家庭成员心理健康的干预措施的效果。
在中国安徽对475名艾滋病病毒感染者和522名家庭成员进行了一项随机对照试验。干预措施包括个体、家庭和社区层面的活动。研究结果包括艾滋病病毒感染者的抑郁症状和应对疾病情况，以及家庭成员的抑郁症状和照顾者负担，在基线以及6个月、12个月、18个月和24个月随访时进行评估。我们使用了具有村庄和参与者层面随机效应的混合效应回归模型来评估干预措施对改善结果指标的效果。
与对照组相比，干预组的艾滋病病毒感染者及其家庭成员报告抑郁症状显著减轻。艾滋病病毒感染者在6个月时抑郁症状差异最大，家庭成员在12个月时差异最大。两种情况下的家庭成员随着时间推移感知到的照顾者负担均有所减轻；然而，组间差异未达到统计学显著性。艾滋病病毒感染者报告干预措施对其应对疾病有显著效果。
该研究强调了使受艾滋病病毒影响的家庭共同而非单独应对挑战的重要性。未来的项目可能最好同时纳入艾滋病病毒感染者及其家庭成员，通过加强家庭内部的互动和支持来最大化干预效果。（PsycINFO数据库记录
