Yehuda S, Carasso R L
Department of Psychology, Bar-Ilan University, Ramat-Gan, Israel.
Int J Neurosci. 1987 Nov;37(1-2):85-8. doi: 10.3109/00207458708991805.
The effects of Delta-Sleep-Induced Peptide (DSIP) were examined in rats kept at 12:12 light:dark schedule. The peak of the circadian pain threshold of saline-treated rats occurred at 10:00. Rats treated with 0.1 mg/kg, i.p. DSIP exhibited a significantly higher pain threshold level (as measured by hot plate) both in the light and dark periods. Prior to the treatment the peak was at 10:00. With treatment the peak shifted to 18:00. A dose of 1.0 mg/kg DSIP increased the pain threshold level only during the dark period. The analgesia induced by DSIP is insensitive to naloxone pretreatment.
在按照12:12光照:黑暗周期饲养的大鼠中研究了δ-睡眠诱导肽（DSIP）的作用。生理盐水处理的大鼠昼夜疼痛阈值峰值出现在10:00。腹腔注射0.1mg/kg DSIP处理的大鼠在光照期和黑暗期均表现出显著更高的疼痛阈值水平（通过热板法测量）。处理前峰值在10:00。处理后峰值移至18:00。1.0mg/kg DSIP的剂量仅在黑暗期提高疼痛阈值水平。DSIP诱导的镇痛作用对纳洛酮预处理不敏感。
