DNA replication and mismatch repair safeguard against metabolic imbalances.
作者信息
Manhart Carol M, Alani Eric
机构信息
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853-2703.
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853-2703
出版信息
Proc Natl Acad Sci U S A. 2017 May 30;114(22):5561-5563. doi: 10.1073/pnas.1705971114. Epub 2017 May 22.
Abstract
摘要
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本文引用的文献
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Alterations in cellular metabolism triggered by or inactivation cause imbalanced dNTP pools and increased mutagenesis.或失活引发的细胞代谢改变会导致 dNTP 池失衡和诱变增加。
Proc Natl Acad Sci U S A. 2017 May 30;114(22):E4442-E4451. doi: 10.1073/pnas.1618714114. Epub 2017 Apr 17.
2
Eukaryotic Mismatch Repair in Relation to DNA Replication.与DNA复制相关的真核生物错配修复
Annu Rev Genet. 2015;49:291-313. doi: 10.1146/annurev-genet-112414-054722.
3
A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands.DNA聚合酶δ在DNA前导链和滞后链复制中的主要作用
Mol Cell. 2015 Jul 16;59(2):163-175. doi: 10.1016/j.molcel.2015.05.038. Epub 2015 Jul 2.
4
Quantifying the contributions of base selectivity, proofreading and mismatch repair to nuclear DNA replication in Saccharomyces cerevisiae.量化碱基选择性、校对和错配修复对酿酒酵母核DNA复制的贡献。
DNA Repair (Amst). 2015 Jul;31:41-51. doi: 10.1016/j.dnarep.2015.04.006. Epub 2015 Apr 25.
5
Nuclear localization of de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNA.从头合成胸苷酸途径的核定位对于防止 DNA 中尿嘧啶积累是必需的。
J Biol Chem. 2011 Dec 23;286(51):44015-44022. doi: 10.1074/jbc.M111.307629. Epub 2011 Nov 4.
6
Glutamine addiction: a new therapeutic target in cancer.谷氨酰胺成瘾：癌症治疗的新靶点。
Trends Biochem Sci. 2010 Aug;35(8):427-33. doi: 10.1016/j.tibs.2010.05.003.
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Elevated dNTP levels suppress hyper-recombination in Saccharomyces cerevisiae S-phase checkpoint mutants.dNTP 水平升高可抑制酿酒酵母 S 期检验点突变体中的超重组。
Nucleic Acids Res. 2010 Mar;38(4):1195-203. doi: 10.1093/nar/gkp1064. Epub 2009 Dec 3.
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DNA polymerases and human disease.DNA聚合酶与人类疾病。
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