Kamaleshwaran Koramadai Karuppusamy, Joseph Jephy, Upadhya Indra, Shinto Ajit Sugunan
Department of Nuclear Medicine, PET/CT and Radionuclide therapy, Comprehensive Cancer Care Center, Kovai Medical Center and Hospital Limited, Coimbatore, India.
Indian J Nucl Med. 2017 Apr-Jun;32(2):125-127. doi: 10.4103/0972-3919.202236.
Metastatic tumor is one of several etiologies of space-occupying masses in the orbit that accounts for 1-13% of all orbital masses. In the adult patient population, breast cancer is the most common tumor to metastasize to the orbit, followed by metastasis from the lung, prostate, and gastrointestinal tract. Carcinoid tumors are rare neuroendocrine neoplasms derived from enterochromaffin cells, which are found primarily in the gastrointestinal tract and bronchial tree. Liver metastases are the classic presentation of distant disease. Although rare, metastatic carcinoid to the extraocular muscles (EOMs) has been relatively well described in both retrospective case reports and clinical series in the ophthalmology literature, but not in nuclear medicine. Positron emission tomography/computed tomography (PET/CT) using Ga-68-labeled somatostatin-analogues have shown superiority over other modalities for imaging of Neuroendocrine tumor We describe a case of bilateral EOM metastasis from carcinoid lung in Ga-68 DOTANOC PET/CT and treatment with Lu -177 DOTATATE.
转移性肿瘤是眼眶占位性肿块的几种病因之一，占所有眼眶肿块的1%至13%。在成年患者群体中，乳腺癌是最常见的转移至眼眶的肿瘤，其次是来自肺、前列腺和胃肠道的转移瘤。类癌是源自肠嗜铬细胞的罕见神经内分泌肿瘤，主要见于胃肠道和支气管树。肝转移是远处疾病的典型表现。虽然罕见，但眼外肌（EOMs）的转移性类癌在眼科文献的回顾性病例报告和临床系列中已有相对充分的描述，但在核医学领域尚未见报道。使用Ga-68标记的生长抑素类似物的正电子发射断层扫描/计算机断层扫描（PET/CT）已显示出在神经内分泌肿瘤成像方面优于其他方法。我们描述了一例在Ga-68 DOTANOC PET/CT中表现为双侧眼外肌转移的类癌肺转移病例，并采用Lu -177 DOTATATE进行治疗。
