Hanson M W, Schneider A M, Enterline D S, Feldman J M, Gockerman J P
Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA.
J Nucl Med. 1998 Apr;39(4):647-50.
Metastatic tumor is one of several etiologies of space-occupying masses in the orbit that accounts for 1%-13% of all orbital masses (1). In the adult patient population, breast cancer is the most common tumor to metastasize to the orbit followed by metastases from the lung, prostate and gastrointestinal tract (2). It is rare for carcinoid tumors to metastasize to the eye or to the orbit. Carcinoid tumors arise from Kulchitsky cells that originate in the neural crest. Histologically, these tumors resemble, but are not as aggressive as, adenocarcinomas. Most carcinoids arise in the gastrointestinal tract or the lung. The most common site for carcinoid metastases is the liver. On anatomical imaging studies, such as CT and magnetic resonance imaging, metastatic orbital carcinoid tumors appear as nonspecific tumor masses. Carcinoid tumors have an affinity for uptake of the radiopharmaceutical 131I-metaiodobenzylguanidine (MIBG) (3). We report a case of a patient with a known carcinoid tumor who developed a left orbital mass that demonstrated abnormal uptake of 131I-MIBG indicative of metastatic carcinoid tumor to the orbit.
转移性肿瘤是眼眶占位性肿块的几种病因之一，占所有眼眶肿块的1%-13%（1）。在成年患者群体中，乳腺癌是最常转移至眼眶的肿瘤，其次是来自肺、前列腺和胃肠道的转移瘤（2）。类癌转移至眼部或眼眶较为罕见。类癌起源于神经嵴的库尔契茨基细胞。从组织学上看，这些肿瘤与腺癌相似，但侵袭性不如腺癌。大多数类癌发生在胃肠道或肺部。类癌转移最常见的部位是肝脏。在解剖学成像研究中，如CT和磁共振成像，转移性眼眶类癌肿瘤表现为非特异性肿瘤肿块。类癌对放射性药物131I-间碘苄胍（MIBG）有摄取亲和力（3）。我们报告一例已知患有类癌肿瘤的患者，其出现左侧眼眶肿块，该肿块显示131I-MIBG摄取异常，提示类癌转移至眼眶。
