Salva Susana, Alvarez Susana
Immunobiotechnology Laboratory, CERELA-CONICET, Tucuman, Argentina.
Applied Biochemistry Institute, Universidad Nacional de Tucumán, Tucuman, Argentina.
Front Immunol. 2017 May 8;8:507. doi: 10.3389/fimmu.2017.00507. eCollection 2017.
The number of granulocytes is maintained by a regulated balance between granulopoiesis in the bone marrow and clearance and destruction in peripheral tissues. Granulopoiesis plays a fundamental role in the innate immune response. Therefore, factors affecting the normal granulopoiesis lead to alterations in innate defenses and reduce the resistance against infections. In this study, we give a description on recent advances regarding the molecular and cellular events that regulate steady-state and emergency granulopoiesis, which are crucial processes for the generation of protective innate immune responses. Particular attention will be given to emergency granulopoiesis alterations in immunosuppression states caused by malnutrition and chemotherapy. The role of microbiota in maintaining a steady-state granulopoiesis and the immunological mechanisms involved are also discussed. Moreover, we describe the findings of our laboratory demonstrating that the dietary supplementation with immunobiotics is an interesting alternative to improve steady-state and emergency granulopoiesis, the respiratory innate immune response, and the resistance against respiratory pathogens in immunocompromised hosts.
粒细胞的数量通过骨髓中粒细胞生成与外周组织中的清除和破坏之间的调节平衡来维持。粒细胞生成在先天性免疫反应中起基本作用。因此，影响正常粒细胞生成的因素会导致先天性防御功能改变，并降低抗感染能力。在本研究中，我们描述了关于调节稳态和应急粒细胞生成的分子和细胞事件的最新进展，这些事件是产生保护性先天性免疫反应的关键过程。将特别关注营养不良和化疗引起的免疫抑制状态下的应急粒细胞生成改变。还讨论了微生物群在维持稳态粒细胞生成中的作用以及相关的免疫机制。此外，我们描述了我们实验室的研究结果，表明补充免疫益生菌饮食是改善免疫功能低下宿主的稳态和应急粒细胞生成、呼吸道先天性免疫反应以及抗呼吸道病原体能力的一种有趣选择。
