巴氯芬诱导的生长激素分泌在慢性精神分裂症患者中受到抑制：精神分裂症中γ-氨基丁酸紊乱的神经内分泌证据。

Baclofen-induced growth hormone secretion is blunted in chronic schizophrenics: neuroendocrine evidence for a GABA disturbance in schizophrenia.

作者信息

Monteleone P, Maj M, Iovino M, Forziati D, Veltro F, Steardo L

机构信息

Mental Health Service U.S.L. 41, Naples, Italy.

出版信息

Psychiatry Res. 1988 Oct;26(1):1-9. doi: 10.1016/0165-1781(88)90081-9.

DOI:10.1016/0165-1781(88)90081-9

PMID:2853397

Abstract

To substantiate a previously reported disturbance of gamma-aminobutyric acid (GABA) in chronic schizophrenia, plasma growth hormone (GH) response to a direct GABA agonist (baclofen, 10 mg) was assessed in 12 unmedicated chronic schizophrenic males and 10 sex- and age-matched healthy controls. Baclofen and placebo were administered orally, in a double-blind design, and blood samples were collected before and 30, 60, 90, 120, 180, and 240 min after drug or placebo administration. Baclofen induced a clear-cut rise in plasma GH levels over baseline values, but the GH increase observed in the patients was significantly smaller than that in controls. These results support the idea that GABA mechanisms may be impaired in chronic schizophrenia.

摘要

为证实先前报道的慢性精神分裂症患者γ-氨基丁酸（GABA）紊乱，对12名未用药的慢性精神分裂症男性患者和10名性别及年龄匹配的健康对照者，评估了血浆生长激素（GH）对直接GABA激动剂（巴氯芬，10毫克）的反应。采用双盲设计口服给予巴氯芬和安慰剂，并在给药前以及给药后30、60、90、120、180和240分钟采集血样。巴氯芬使血浆GH水平明显高于基线值升高，但患者中观察到的GH升高显著小于对照组。这些结果支持慢性精神分裂症患者GABA机制可能受损的观点。