Monteleone P, Maj M, Iovino M, Steardo L
Mental Health Service, U.S.L. 41, Naples, Italy.
Acta Endocrinol (Copenh). 1988 Nov;119(3):353-7. doi: 10.1530/acta.0.1190353.
Evidence has been provided supporting the existence of a sex-related difference in the GH secretion following different GH-releasing stimuli. Since pharmacological activation of the endogenous gammaaminobutyric acid (GABA) system results in increased basal GH release in humans, the present study was undertaken to investigate whether a sex difference is present in the GH response to GABAergic stimulation. Sixteen healthy subjects (8 women and 8 men) received orally 10 mg of baclofen, the direct GABAB agonist which freely crosses the blood-brain barrier. Blood samples were collected before (T = -30 and 0) and 30, 60, 90, 120 and 180 min after the drug administration for plasma GH measurements. Following baclofen administration, plasma GH rose in healthy males (F = 19.417, P less than 0.0001), but not in females (F = 1.67, NS). These results suggest that GABA modulation of human GH release is sex-dependent.
已有证据支持在不同生长激素释放刺激后生长激素分泌存在性别差异。由于内源性γ-氨基丁酸（GABA）系统的药理学激活会导致人类基础生长激素释放增加，因此本研究旨在调查生长激素对GABA能刺激的反应是否存在性别差异。16名健康受试者（8名女性和8名男性）口服10毫克巴氯芬，这是一种可自由穿过血脑屏障的直接GABAB激动剂。在给药前（T = -30和0）以及给药后30、60、90、120和180分钟采集血样以测量血浆生长激素。服用巴氯芬后，健康男性的血浆生长激素升高（F = 19.417，P小于0.0001），而女性则未升高（F = 1.67，无统计学意义）。这些结果表明，GABA对人类生长激素释放的调节存在性别依赖性。
