圆锥绣球茎的化学成分。
Chemical constituents from the stems of Hydrangea paniculata.
作者信息
Ma Jie, Sun Hua, Li Chuang-Jun, Yang Jing-Zhi, Chen Fang-You, Zhang Dong-Ming
机构信息
a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
出版信息
J Asian Nat Prod Res. 2017 Jun;19(6):564-571. doi: 10.1080/10286020.2017.1329829.
Further study on the constituents from the stems of Hydrangea paniculata Sieb resulted in isolation of two new compounds 1-2, including 1 monoterpenoid and 1 phenolic glycoside, along with 10 known compounds. Their structures were elucidated on the basis of spectroscopic data, including UV, IR, MS, and NMR experiments, along with chemical methods. At 10 μM, compounds 1 and 2 exhibited comparable activities with bicyclol in vitro assays for hepatoprotective activity against APAP-induced HepG2 cell damage.
对圆锥绣球茎的成分进行进一步研究，从中分离出两种新化合物1 - 2，包括1个单萜类化合物和1个酚苷，以及10个已知化合物。通过紫外光谱（UV）、红外光谱（IR）、质谱（MS）和核磁共振（NMR）实验等光谱数据以及化学方法确定了它们的结构。在10 μM浓度下，化合物1和2在体外实验中对乙酰氨基酚诱导的HepG2细胞损伤的肝保护活性方面表现出与双环醇相当的活性。
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