Wang Yang, Wu Yanping, Wang Yuanyuan, Xu Han, Mei Xiaoqiang, Yu Dongyou, Wang Yibing, Li Weifen
Key Laboratory of Molecular Animal Nutrition of the Ministry of Education, Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
Nutrients. 2017 May 19;9(5):521. doi: 10.3390/nu9050521.
Oxidative stress defines a condition in which the prooxidant-antioxidant balance in the cell is disturbed, resulting in DNA hydroxylation, protein denaturation, lipid peroxidation, and apoptosis, ultimately compromising cells' viability. Probiotics have been known for many beneficial health effects, and the consumption of probiotics alone or in food shows that strain-specific probiotics can present antioxidant activity and reduce damages caused by oxidation. However, the oxidation-resistant ability of probiotics, especially the underling mechanisms, is not properly understood. In this view, there is interest to figure out the antioxidant property of probiotics and summarize the mode of action of probiotic bacteria in antioxidation. Therefore, in the present paper, the antioxidant mechanisms of probiotics have been reviewed in terms of their ability to improve the antioxidant system and their ability to decrease radical generation. Since in recent years, oxidative stress has been associated with an altered gut microbiota, the effects of probiotics on intestinal flora composition are also elaborated.
氧化应激是指细胞内促氧化剂与抗氧化剂平衡被打破的一种状态，会导致DNA羟基化、蛋白质变性、脂质过氧化和细胞凋亡，最终损害细胞活力。益生菌具有多种有益健康的作用，单独食用或添加到食物中时，特定菌株的益生菌可呈现抗氧化活性，并减少氧化造成的损害。然而，益生菌的抗氧化能力，尤其是其潜在机制，尚未得到充分了解。鉴于此，人们有兴趣弄清楚益生菌的抗氧化特性，并总结益生菌在抗氧化方面的作用模式。因此，本文从益生菌改善抗氧化系统的能力及其减少自由基产生的能力方面，对抗氧化机制进行了综述。此外，由于近年来氧化应激与肠道微生物群改变有关，本文还阐述了益生菌对肠道菌群组成的影响。
